Conclusion:Hematologic side effects are frequently induced by the atypical antipsychotic clozapine. Next to agranulocytosis, a progressive and potentially lethal hematologic adverse effect, most of the WBC disorders are transient and appear to be harmless. 展开 ...
which may lead to falls and, consequently, fractures or other injuries. For patients with diseases, conditions, or medications that could exacerbate these effects, complete fall risk assessments when initiating antipsychotic treatment and recurrently for patients on longÂterm antipsychotic therapy. ...
Clozapine caused a decrease in maternal body weight but had no effects on litter size or body weights of either F1or F2 generations at doses up to 0.4 times the MRHD of 900 mg/day on a mg/m² body surface area basis. Nursing Mothers FAZACLO is present in human milk. Because of ...
Food does not appear to affect rate or extent of absorption of conventional tablets. High-fat meal does not have clinically important effects on the pharmacokinetics of orally disintegrating tablets or oral suspension.Plasma ConcentrationsCorrelations between steady-state plasma concentrations and ...
On day 36 while receiving clozapine 200 mg/day, a significant decrease in WBC and absolute neutrophil counts to 1.93 and 0.876 K/µL, respectively, was noted on weekly monitoring. A haematologist was consulted and clozapine was withdrawn immediately. On day 39, while the woman's neutropenia...
The Chempaq Express Blood Counter (Chempaq XBC) is a point-of-care device providing counts of white blood cells (WBC) and granulocytes based on a capillary blood sampling. A randomized cross-over trial design was used comparing capillary blood sampling using a point-of-care device with ...
Lindstrom IH. The effects of long-term treatment with clo- zapine in schizophrenia: a retrospective study in 96 patients treated with clozapine for up to 13 years. Acta Psychiatr Scand 1987;77:524-529.Lindstrom LH. The effect of long-term treatment with clozapine in schizophrenia: a ...
Serum concentrations of clozapine and its major metabolites: effects of cotreatment with fluoxetine or valproate. Serum concentrations of clozapine, norclozapine, and clozapine-N-oxide were assayed in psychotic patients treated with clozapine alone (N = 17), clozapine ... F Centorrino,RJ Baldessarini...
Clozapine in daily oral doses of 20 or 40 mg/kg to rats and rabbits had no teratogenic effects and no influence on the fertility of male and female rats. At 40 mg/kg, however, clozapine inhibited growth of suckling young of treated mothers. Fertility of F1 treated mothers was normal and...
2017, Side Effects of Drugs Annual Citation Excerpt : A case of a 37-year-old male who developed late-onset agranulocytosis after 11 years on clozapine and successfully treated with granulocyte stimulating factor (GSF) is reported [166A]. A case of a 61-year-old male with neutropenia after...