Factor Vila is thought to be the physiologic initiator of the clotting cascade by acting at the surface of a TF-bearing cell and generating the initial amount of thrombin that then diffuses to platelets to activate and prime them for the propagation phase of thrombin generation. Therapeutically,...
Generally, the blood components participating in what has been referred to as the “coagulation cascade” are proenzymes or zymogens, i.e. enzymatically inactive proteins that are converted into an active form by the action of an activator. One of these coagulation factors is FVII. FVII is ...
Regarding the generation mechanism, fibrin fibers were initiated upon the blood/plasma contact with CNFs. Exposure to CNFs would trigger an extrinsic coagulation cascade reaction, causing the formation of thrombin from prothrombin, and subsequently converting fibrinogen into fibrin monomer26. Fibrin monome...
The chimeric protein of the invention can activate any member of a coagulation cascade. The clotting factor can be a participant in the extrinsic pathway, the intrinsic pathway or both. In one embodiment, the clotting factor is factor VII or factor VIIa. Factor VIIa can activate factor X ...
It is assumed that the breaking strength reaches a maximum value when the first bubble of a cascade reaches a diameter equal to the internal diameter of the tube Dt (centimeters). Furthermore, the fibrin breaking strength is assumed to be proportional to the tube circumference, so that the ...