Regarding the generation mechanism, fibrin fibers were initiated upon the blood/plasma contact with CNFs. Exposure to CNFs would trigger an extrinsic coagulation cascade reaction, causing the formation of thrombin from prothrombin, and subsequently converting fibrinogen into fibrin monomer26. Fibrin monome...
Blood clotting involves more than a dozen proteins known to take part in a cascade of chemical reactions inside blood vessels following injury, with each factor, or complex of factors, activating the next in the chain. Named for roman numerals, these clotting factors include factor VIII, which ...