Generally, the blood components participating in what has been referred to as the “coagulation cascade” are proenzymes or zymogens, i.e. enzymatically inactive proteins that are converted into an active form by the action of an activator. One of these coagulation factors is FVII. FVII is ...
The chimeric protein of the invention can activate any member of a coagulation cascade. The clotting factor can be a participant in the extrinsic pathway, the intrinsic pathway or both. In one embodiment, the clotting factor is factor VII or factor VIIa. Factor VIIa can activate factor X ...
Regarding the generation mechanism, fibrin fibers were initiated upon the blood/plasma contact with CNFs. Exposure to CNFs would trigger an extrinsic coagulation cascade reaction, causing the formation of thrombin from prothrombin, and subsequently converting fibrinogen into fibrin monomer26. Fibrin monome...
It is a question as to whether or not the cascade theories promoted progress of coagulation research. However, even a wrong theory my inspire to challenge and thus be fruitful. At this point of time, it seemed that the clinical role of FV − a very rare deficiency causing prolonged ...