Generic Name Clorazepate Brand Name Azene, Tranxene Class Anxiolytic Proposed Mechanism(s) of Action Binds to benzodiazepine receptors at the GABA-A ligand-gated channel, thus allowing for neuronal hyperpolarization. Benzodiazepines enhance the inhibitory action of GABA via boosted chloride conductance. ...
摘要: Summary This chapter contains sections titled: Introduction Chemistry Mechanism of action Pharmacokinetics Drug interactions Serum level monitoring Efficacy Tolerance Adverse effects Place in current therapy References关键词: benzodiazepines for chronic treatment drug interactions serum level monitoring ...
▪ Mechanism Enhances GABA effects by binding to benzodiazepine receptors ▪ Dosage with Qualifiers Anxiety—15-60mg PO qd in divided doses Alcohol withdrawal—30mg ×1, then 30-60mg/d in divided doses • Contraindications—hypersensitivity to drug or class, substance abuse, glaucoma, acute...
benzodiazepines in epilepsy in children and adultsSummary This chapter contains sections titled: Introduction Chemistry Mechanism of action Pharmacokinetics Drug interactions Serum level monitoring Efficacy Tolerance Adverse effects Place in current therapy Referencesdoi:10.1002/9781444316667.ch33Peter Camfield...