Patients will be randomized to receive daily clopidogrel 75 mg or placebo, in addition to daily aspirin 162 mg, for a one year duration starting on the day of surgery (as soon as postoperative bleeding has been excluded). At the end of one year, all patients will undergo coronary ...
Clopidogrel is metabolized much more after a repeated 75 mg oral dose. Plasma concentration of the parent compound is very low and generally below the quantification limit beyond 2 hours after dosing. The main circulating metabolite is the carboxylic acid derivative (Fig. 3), which has no effect...
Patients were administered 300 mg aspirin and 300 mg clopidogrel after initial diagnosis of ischemic stroke and subsequently received 100 mg aspirin and 75 mg clopidogrel daily for 12 weeks, then, we assessed clinical and laboratory resistance to aspirin and clopidogrel. Clinical resistance was evaluate...
Using central randomization, patients were allocated to receive a 300-, 600-, or 900-mg oral clopidogrel LD on the morning of day 1. Twenty-four hours after the LD, all patients were started on a regimen of clopidogrel 75 mg/day and ASA ≤100 mg/day. Low molecular weight heparin was ...
A 79-year-old female patient had used aspirin (100 mg/day) for cerebral infarction and then a dual antiplatelet regimen of aspirin and clopidogrel (75 mg/day) because of severe stenosis in both anterior cerebral arteries. Two weeks later, the patient presented with dyspnea started 3 days ago...
Patients over 18 years old with diagnosed CHD and under clopidogrel (75 mg/d) treatment over 12 months were included. Patients who met one of the following criteria were excluded: (1) anemia (hemoglobin < 90 g/L); (2) platelet count < 100 × 109/L, or with hematological...
The tested tablets of CLP containing 25 mg of sieved (180–250 μ m) CLP particles and 75 mg PVP/VA parti- cles were prepared. The PVP/VA powder was sieved to obtain samples portions with an average size of 150 μ m. Although CLP particles were sieved by the same mesh...
Methods Thirty healthy volunteers were randomised to ticagrelor 90 mg bd (n = 10), clopidogrel 75 mg od (n = 10) or no antiplatelet medications (controls; n = 10) for one week. E. coli endotoxin (LPS) 2 ng/kg was then administered intravenously. Plasma fibrin clot density was assessed...
mg oral loading dose of clopidogrel followed by 75 mg per day before the PCI15,21. And platelet reactivity testing is not recommended before day five unless using a starting dose of 300 or 600 mg at day 1 due to the feared “false rate of non- or low- responders”. These ...
Download: Download full-size image Figure 2. Outcomes in older and younger patients according to treatment: dabigatran 110 mg dual therapy. CRNMBE = clinically relevant nonmajor bleeding event; DE = dabigatran etexilate; DTE = death or thromboembolic event; ISTH = International ...