Some loss of effect may occur during the course of treatment; dose adjustments may reestablish efficacy in some patients.Use: Alone or as an adjunct in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures ...
Animal Data: In three studies in which clonazepam orally disintegrating tablets was administered orally to pregnant rabbits at doses of 0.2, 1, 5 or 10 mg/kg/day (low dose approximately 0.2 times the maximum recommended human dose of 20 mg/day for seizure disorders and equivalent to the maxi...
Plasma harvested from blood was analyzed by simple rapid, selective and validated liquid chromatography-electrospray mass spectrometry (LC-ESI-MS/MS) using diazepam (CAS 439-14-5) as an internal standard.The calibration curves were found to be linear in the range of 1–25 ng/ml and 1–10 ...