Side effects include marked sedation, cardiovascular effects, and anticholinergic effects (e.g., constipation, dry mouth, blurred vision, urinary retention). Clomipramine is dose dependently associated with a higher risk of seizures than other tricyclics; like other tricyclics, it has a high poten...
The treatment regimens described below are based on those used in controlled clinical trials of Anafranil in 520 adults, and 91 children and adolescents with OCD. During initial titration, Anafranil should be given in divided doses with meals to reduce gastrointestinal side effects. The goal of...
When clomipramine and an antipsychotic agent were used concomitantly, the cases sometimes were considered to be examples of neuroleptic malignant syndrome (NMS).Hepatic EffectsPotentially clinically important elevations (e.g., >3 times ULN) in serum ALT and AST concentrations; severe hepatic injury and...
15.The companies, including those that make clomipramine, have denied the states’ allegations. 16.OBJECTIVE : To compare the efficacy and side effects of sertraline and clomipramine in treatment of OCD. 目的: 比较舍曲林和氯丙咪嗪治疗强迫症的疗效和不良反应....
Doses were adjusted according to therapeutic effect and side-effects. Primary efficacy measures were the Yale-Brown Obsessive-Compulsive Scale and the National Institute of Mental Health Obsessive-Compulsive Scale. Secondary efficacy measures were the Montgomery-Asberg Depression Rating Scale, Symptom Check...
Plasma levels, side effects and outcome. Forty obsessive-compulsive ritualizers received nightly placebo or clomipramine up to 225 mgs nocte for 8 months, and received behavioural treatment (exposure to vivo) from weeks 4 to 10. Plasma concentrations of clomipramine and its pri... RS Stern,IM ...
Forty of these did so because of intolerable side-effects, 10 did not return for follow-up, 5 'got better' before the conclusion of the trial and 3 had to be pre scribed additional therapy. Of the 149 patients who completed the study, 74 received capsules and 75 tablets. The two ...
This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent.|A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the ...
Duloxetine and clomipramine were both effective in general while duloxetine is of quicker effect and lower rate of side effect occurrence.Conclusions Duloxetine is worthy of wide application in treating the depression of AD as it shares the same effect with clomipramine but has less side effects ...
Objective To compare the efficacy and side effects of sertraline and clomipramine in the treatment of patients with refractory obsessive-compulsive disorde... Q Chuan-Sheng,JY Pan - 《Chinese Journal of Modern Drug Application》 被引量: 2发表: 2010年 Clomipramine versus sertraline in the treatment...