Clomiphene is a Selective Estrogen Receptor Modulator. It acts on the hypothalamus to cause an increase in follicle stimulating hormone and luteinizing hormone which results in ovulation. Hence it is used for people experiencing anovulation. It also acts to increase testosterone levels in men. Clomiph...
Clomid is a synthesized product, first discovered in 1960 and quickly approved and put on sale. The direct purpose of Clomid is the treatment of infertility in women by stimulating the ovulation process, and the therapy of oligospermia in men. Clomid has
Nevertheless, although off-label, clomiphene citrate (CC), a selective estrogen receptor modulator, has also been used, mainly when fertility is an issue. The aim of this study is to evaluate the effectiveness of CC in recovering the gonadal axis in men with macroprolactinoma, with or without...
The Phase 2 clinical study is a double-blind randomized placebo-controlled dose finding study evaluating daily oral doses of Zuclomiphene (10mg versus 50mg) in men with advanced prostate cancer who have ADT induced moderate to severe hot flashes. The clinical study has a treatment duration of 12...
Infertility in men can be caused by different factors and is typically evaluated by a semen analysis. Can the fertility drug clomiphene citrate help treat male infertility? The authors favor use of letrozole as first line therapy due to comparable clinical pregnancy rates and the advantage of ...
Nervous system abnormalities: neural tube defects (anencephaly, meningomyelocele),microcephaly, and hydrocephalus Renal abnormalities: renal agenesis and renal dysgenesis Others: dwarfism, mental retardation Gastrointestinal:Pancreatitis Genitourinary:Endometriosis, ovarian cyst (ovarian enlargement or cysts could...
Men treated with CC for at least 3 months were included if they presented with: RESULTS: 18 patients met the inclusion criteria. CC was prescribed for 3 months at the dose of 50mg every 48h. Plasma T level was assessed at baseline and after 1 month of CC administration. Semen parameters...
RESULTS 96 men with a mean age 61±7 (50-70) years were analyzed. Comorbidities: hypertension 36%, diabetes 14%, dyslipidemia 39%. Baseline/treatment levels were: total T 242±47/492±200; Estradiol 42±16/39±24; LH 2.8±2.6/7.8±2.9 (p < 0.01 for all). With CC administration, ...
Participants were randomized in a 1:1 ratio, to either the combination of 2.5mg letrozole and 50mg Clomiphene Citrate (CC) daily or 2.5mg letrozole alone from 2nd to 6thday of menstrual cycle for up to three treatment cycles. The primary outcome was ovulation rate per cycle. The secondary ...
Patients and Methods: A total of 282 men with hypogonadism, wishing to preserve their fertility, were randomized to one of three treatment arms: CC 50mg (n = 95); 5000IU hCG injections twice weekly (n = 94); or a combination of both therapies (CC + hCG; n = 94). All pa...