A total of 178 men with secondary hypogonadism and ED received clomiphene citrate for 4 months. Sexual function improved in 75%, with no change in 25%, while significant increases in luteinizing hormone (P<0.001) and free testosterone (P<0.001) occurred in all patients. Multivariable analysis s...
For men with idiopathic oligospermia, where clomiphene has been shown to be effective, the mechanism of action is quite similar with the difference that the most important effect is at the level of the testicles, where testosterone and sperm production is increased. The volume and density increas...