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The mechanisms of the diurnal variation in PAI-1 activity have been well studied. We and other groups analyzed the roles of the molecular clock in circadian PAI-1 activation.7,69 PAI-1 mRNA and protein levels clearly reflect a circadian rhythm in the heart and aorta with a peak expression ...
Dynamic PER repression mechanisms in the Drosophila circadian clock: from on-DNA to off-DNA. Genes Dev. 24, 358–367 (2010). Article CAS PubMed PubMed Central Google Scholar Ye, R. et al. Dual modes of CLOCK:BMAL1 inhibition mediated by cryptochrome and Period proteins in the mammalian...
Also, near-constant photoperiod (23 L:1 D) increases stress and fear levels in Ross 308 broilers chickens [7], disrupts circadian clock gene expression and cecal microbiome diversity in Hy-Line Brown Layer chickens [8]. Nevertheless, the mechanisms underlying constant or near-constant light-...
Posttranslational mechanisms regulate the mammalian circadian clock. Cell. 2001;107:855–67. 38. Watson J. Oxidants, antioxidants and the current incurability of metastatic cancers. Open Biol. 2013;3:120144. 39. Miki T, Matsumoto T, Zhao Z, Lee CC. p53 regulates Period2 expression and the...
Clocks can be mechanical, electronic, or atomic, showcasing a wide range of mechanisms to suit various needs and preferences. Chronometers, however, are specifically designed to maintain their accuracy under conditions of temperature changes, humidity, and motion, often employing mechanical movements fi...
Although ganglion cells, the output neurons of the retina that signal more central brain areas, indirectly receive both rod and cone input, the synaptic mechanisms and neural circuits that mediate the switch between rod pathway function at night and cone pathway function in the day remain largely ...
Axon regeneration of dorsal root ganglia (DRG) neurons after peripheral axotomy involves reconfiguration of gene regulatory circuits to establish regenerative gene programs. However, the underlying mechanisms remain unclear. Here, through an unbiased survey, we show that the binding motif of Bmal1, a...
A circadian oscillator exhibits persistent rhythmical activity with a near 24 h periodicity under constant conditions [2]. The universal mechanisms of circadian clocks are transcriptional/translational feedback loops [3]. In mammals, daily biological rhythms are generated at the mol...
Accordingly, there would be a selective advantage in increasing loop number and complexity, as well as on mechanisms that would enable this, e.g. gene duplication [79, 80]. In this perspective, the circadian clock in P. patens may well represent an antecedent state comprising a single loop ...