Importantly, changes in cellular levels of small metabolites, such as lipids and the intermediate metabolite SAM, have a direct influence on lifespan and age-associated phenotypes, through robust remodeling of chromatin structures [187]. Metabolic shifts that occur with aging impact epigenetic finger...
with an enzyme that promotes the formation of cellular fibers and regulates cell shape and motility. The overexpression of these clock proteins in cancers increases the levels of this enzyme, which changes F-actin structures inside cells. This promotes cancer cell proliferation, migration, and ...
“With the clock ticking on the biodiversity crisis, and the UK already one of the most nature-depleted countries in the world, we must move further and faster. Absolutely key is supporting farmers to transition away from chemical dependence and towards more nature-friendly methods of producti...
被引量: 0发表: 2023年 Individual decisions drive the changes in movement patterns of ground beetles between forestry management types , such as preparation (partial) cuts and clear cuts, on the selected population of the forest ground beetle, Carabus coriaceus (Coleoptera: Carabidae). ... Z El...
In June 2023, Microchip Technology Inc. launched the 5071B cesium atomic clock that can carry out autonomous timekeeping for months in the instance of GNSS denials. In June 2022, Orolia SA, a subsidiary of Safran, introduced an upgraded edition of its small size, weight, power, and cost (...
Notably, patients with bipolar disorder show cyclic changes in sleep, activity, eating, and hormone secretion during periods of relapse, emphasizing potential circadian control. Table 3. Polymorphisms in BMAL1, CLOCK, CK1δ/ε, associated with human phenotypesa Gene symbol (chromosome)SNPSample size...
Otherwise use the average of neighbouring time points between which the sign of the first derivative changes as the indices of the turning points; For each set of peaks and troughs (turning points), calculate the time differences between neighbouring turning points, average these differences and ...
At the molecular level, deletion of Bmal1 in podocytes caused transcriptional and functional changes indicative of impaired glomerular function.57 Transcriptomic analyses of glomeruli isolated from wild-type and Bmal1 knockout kidneys across 1 circadian cycle revealed differential expression of multiple ...
Consumer Duty will require firms to review their range of products, how they communicate, and to consider changes in areas including governance and accountability, reporting, product design, distribution, servicing, and staff training. Absolute and relative It is important for firms to understand the...
Circadian rhythms are endogenously generated, and can be entrained by external cues, called Zeitgebers, the primary one of which is daylight. These rhythms allow organisms to anticipate and prepare for precise and regular environmental changes. ...