B.PharmacologyP.PharmacologyKennedyPharmacologyB.PharmacologyE.PharmacologyLeonardPharmacologyWileyDrug Development ResearchKennedy BP, Leonard BE (1982) Effects of clobazam and other benzodiazepines on γ-aminobutyric acid turnover in stressful and non stressful situation. Drug Dev Res (Suppl 1):101...
The use of benzodiazepines, including clobazam, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death. Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an in...
misuse, and addiction, which can lead to overdose or death. Abuse and misuse of benzodiazepines often (but not always) involve the use of doses greater than the maximum recommended dosage and commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is asso...
Limit dosage and duration of concomitant use of benzodiazepines and opioids, and follow patients closely for respiratory depression and sedation [see Warnings and Precautions (5.1)]. 7.2 CNS Depressants and Alcohol Concomitant use of clobazam with other CNS depressants may increase the risk of ...
KEY WORDS: Drop seizures, Antiepileptic drug, Benzodiazepines, Clinical trials, Epi- lepsy. Lennox-Gastaut syndrome (LGS) is a complex, chronic epileptic encephalopathy that often requires decades of polytherapy. 1,2 The most common seizure types associ- ated with LGS are tonic and atonic seizur...
explain some of these clinical differences. The functional properties of the two 1,5-benzodiazepines were characterized at the human γ-aminobutyric acid type A receptor (GABA A R) subtypes α 1 β 2 γ 2S , α 2 β 2 γ 2S , α 3 β 2 γ 2S , α 5 β 2 γ 2S and α 6 β...
40 ANALYSIS OF FLUVOXAMINE, CLOBAZAM AND OTHER BENZODIAZEPINES ON THE SAME HPLC SYSTEMAcoustic noise measurementAn abstract is unavailable. This article is available as a PDF only.doi:10.1097/00007691-199508000-00053Vandenberghe, HMacDonald, J C...
Data for other benzodiazepines suggest the possibility of long-term effects on neurobehavioral and immunological function in animals followingprenatalexposure to benzodiazepines at clinically relevant doses. The background risk of major birth defects and miscarriage for the indicated population is unknown. ...
Clobazam (CLB) is a well characterized antiepileptic drug (AED) that differs from other benzodiazepines by its basic chemical structure and pharmacodynamic properties. Only one previous study examined the efficacy of CLB as add-on therapy in refractory status epilepticus (RSE). We analyzed RSE ...
(i.e., a higher dose of a drug is required to produce the same effect that was once obtained at a lower dose). Tolerance to the therapeutic effect of ONFI may develop; however, little tolerance develops to the amnestic reactions and other cognitive impairments caused by benzodiazepines. ...