Dose adjustment of drugs metabolized by CYP2D6 (e.g. dextromethorphan, nebivolol, paroxetine, and pimozide) may be necessary, as clobazam is a weak CYP2D6 inhibitor. With alcohol/food There is an increased sedative effect when clonazepam or clobazam are given with alcohol, and it is recommended...
In humans, this conversion occurs much more slowly with blood concentrations of CBZ exceeding those of NDMC for more than 24 h after a single oral dose of 20 or 30 mg CBZ (Besson et al., 2015, Pullar et al., 1987). It is hence likely that, in humans, treatment with NDMC – ...
Dose adjustment of drugs metabolized by CYP2D6 (e.g. dextromethorphan, nebivolol, paroxetine, and pimozide) may be necessary, as clobazam is a weak CYP2D6 inhibitor. With alcohol/food There is an increased sedative effect when clonazepam or clobazam are given with alcohol, and it is recommended...