Methods: Sixty-eight patients with LGS aged 2–26 years were administered CLB (low dose = target 0.25 mg/kg/day; high dose = target 1.0 mg/kg/day). The study consisted of 4-week baseline, 3-week titration, and 4-week maintenance periods, followed by a 3-week taper or continuation ...
Clobazam or its metabolite N -desmethylclobazam was dissolved in the extracellular solution and applied for 2 s by pressure ejection from a micropipette. To maintain GABA-activated currents, 2 m M Mg adenosine triphosphate (ATP) was added to the intracellular solution. Results : GABA elicited ...
Subjects were administered acute single doses of 20 mg clobazam or matching placebo, in a counterbalanced double-blind design. Anxiety levels on the individual personal constructs of anxiety were measured 2 h after drug administration. There was a significant ANOVA interaction effect between drug ...
The effects on memory and psychomotor performance and the subjective effects of three anxiolytic benzodiazepines (lorazepam 2 mg, diazepam 10 mg and clobazam 20 mg p.o.) have been evaluated in a double-blind, placebo-controlled, cross-over study in 10 healthy volunteers. At each session, ...
Three anxiolytic drugs (bromazepam 3 mg, buspirone 10 mg, and clobazam 10 mg p.o.) were evaluated for their effects on memory, psychomotor performance and subjective response in a double-blind, placebo-controlled, crossover study in 20 healthy volunteers. At each session, measurements were made...
Clobazam/etravirine interaction: First report of an interaction, leading to neurotoxicity: case report
Ardakani , Majid Shohrati , Lida Hakemi , Gheise Badri and Maryam Mokhberi , Pharmacokinetics and Bioequivalence Study of Clobazam 10 mg Tablet, International Journal Of Pharmacology, 2(5):481-484,2006. 5. Parag. S. Mahadik*1, Senthilkumar. G. P1, Devprakash Dahia1, T. Tamizh Mani1...
Pharmacokinetics and bioequivalence study of clobazam 10 mg tablet. Int J Pharmacol. 2006;5:481-4.M. Rezarouini, Y. Ardakani, M. Shohrati, and L. Hakemi, "Pharmacokinetic and bioequivalence study of clobazam 10 mg tablet," International Journal of pharmacology, vol. 2, pp. 409- 481, ...
71 mg/kg. Nine cases (primary generalized epilepsy 2/2, secondary generalized epilepsy 7/29) were completely free from seizures, and another 9 (secondary generalized epilepsy 8/29, partial epilepsy 1/5) experienced a decrease of 50% or more in seizure frequency. Seizure frequency did not ...
Clobazam at oral doses of 5 to 80 mg/kg caused a marked increase in locomotion (79% to 122%) under MOTEX conditions, whereas results with the hole-board device were inconsistent and misleading: Enhanced locomotion was represented as reduced motor activity in terms of light-beam crossings. ...