Sample size tables for exact single-stage phase II designs. Stat Med. 2001;20(6):859–66. Article PubMed Google Scholar Hillmen P, et al. A randomized phase II trial of fludarabine, cyclophosphamide and mitoxantrone (FCM) with or without rituximab in previously treated chronic lymphocytic ...
To directly test this hypothesis, we performed joint single-cell DNAme sequencing and whole transcriptome sequencing on additional normal B and CLL samples (n = 96 cells [1 sample], n = 288 cells [2 samples], respectively; Fig. 3b; Supplementary Fig. 3c). While MI was higher ...
A second important question raised by this study is the extent to which Dnmt3aΔ/Δ mouse CLL and PTCL models are similar to human disease. The development of CLL in the absence of Dnmt3a is consistent with find- ings that Dnmt3a belongs to the top 1% of underexpressed genes in human ...
The observation that B-CLL cells uniquely express functional levels of EPAC among hematopoietic cells raises the question as to whether EPAC expression confers a proliferative or survival advantage on B-CLL cells relative to their nontransformed B-cell counterparts. Prior studies demonstrated that both...
The answers to this question will help to estabUsh a I(ICCies-specIfic ontogeny and early behaviour catalogue lor man, 10 that lie caD be asiJgned a place In a phylogenyof such catalogues. SecoDd" wItat II It about th~ huntin, and ptherinll lVay of lite. IVhlch domlnaled mon: ...
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