Ten years ago, diagnosis of chronic lymphocytic leukemia (CLL) meant treatment with chemotherapy and, for most patients, a shorter life expectancy than before diagnosis. Today, those are no longer foregone conclusions. The past decade has seen the FDA approve a handful of new targeted therapies ...
Patients in the chemoimmunotherapy group received six cycles of treatment, with patients older than 65 years receiving intravenous bendamustine (90 mg/m2, days 1-2), whereas patients aged 65 years or younger received intravenous fludarabine (25 mg/m2, days 1-3) and intravenous ...
where we met with Dr. Jeffrey Kopelson. I’m sorry to say that he died several years ago, suddenly, from a heart attack. While I wanted to have B-17 via IV treatment, he advised against it, as it requires many visits and would have been useless during our three-day...
Relapse and NRM contributed equally to treatment failure. Five-year mortality for 45- and 65-year-old reference patients who were event-free at the 5-year landmark was 8% and 47% compared with 3% and 14% in the matched general population, respectively. The prospect of long-term disease-...
We report a randomized prospective phase 3 study (CLL7), designed to evaluate the efficacy of fludarabine, cyclophosphamide, and rituximab (FCR) in patients with an early-stage high-risk chronic lymphocytic leukemia (CLL). Eight hundred patients with untreated-stage Binet A disease were enrolled ...
Timing of hepatitis C antiviral therapy in patients with advanced liver disease: A decision analysis model Antiviral therapy for the treatment of hepatitis C virus (HCV) infection is used before and after liver transplantation. The objective of this study was to... S Saab,DR Hunt,MA Stone,.....
EHA教育文集-CLL (2)
Study design: Patients were recruited after informed consent at the end of any Rituximab-containing induction treatment in 1st or 2nd line that achieved at least a PR. Excluded were patients with uncontrolled bacterial or viral infections and conditions that might severely affect life-expectancy (...
offer. Please keep in mind that just about everything on this site goes just fine with conventional medicine. In fact one of my earliest friends on this site went through rounds of conventional treatment and is now doing well by keeping her health well and together via natural self-help ...
The presence of ongoing SHM or CSR in the context of CLL may support the functionality of DNA damage repair pathways, with potential relevance to therapeutic strategies.