Have you started using this test more often? Anthony Mato, MD, MSCE:I’d love to say I’ve made a firm decision, but honestly, the next-generation sequencing panel at MSK [Memorial Sloan Kettering Cancer Center] is pretty much one size fits all, so if you send it, you get everything...
using 5000 bootstrapped datasets sampled from each respective cohort (See Methods), white square is the mean, centre line is the median, bounds of box are the interquartile range and black dots are outliers. We performed model comparison using a one-tailed Mann–Whitney U-test on the mean di...
And now this site…At the urging of my husband/mentor/coach/favorite nag, I’ve decided to create this website to put out all the information I’ve discovered — all in one place. For those of us with CLL leukemia, our second greatest enemy is fear. The more you know, the ...
sgRNA-B in green). PCR primers used for detection of the deletion are indicated by arrows. Lower panel shows a diagram with the steps for the generation of an HG3-del(11q) cell line. Single-cell sorted clones
MRD levelIGHV-MSB2M (mg/L)ZAP70FISH subtype 0.98 × 10−6 detectable Unmutated 3.1 Positive Negative 0.90 × 10−6 detectable Unmutated 5.9 Positive Del(11q) Undetectable (limit of detection 1.9 × 10−6) Unknown 7.7 Positive Trisomy 12 6.78 × 10−6 Unmutated 3.1 Unknown Trisomy 12...
FISH and TP53 mutational status have been repeated before ibrutinib inception in all patients. IGHV mutational status was not generally evaluated more than once. Cytogenetic analysis was performed in all patients but 11q is not routinely assessed. According to the recently updated International Work...