BCR在临床环境中引入后,一些CLL患者的预后有所改善,尽管它们与高毒性率相关,并且通常使用到患者的疾病进展。 在随机 3 期 VENICE-1 试验(ClinicalTrials.gov 标识符:NCT02756611)中,研究人员探讨了维奈托克在复发或难治性 CLL 患者中是否安全有效,无论他们是否接受过 BCRi 治疗。 总体而言,2016 年至 2022 年期间...
参考文献: [1]Allan JN, Shanafelt T, Wiestner A, et al. Long-term efficacy of first-line ibrutinib treatment for chronic lymphocytic leukaemia in patients with TP53 aberrations: a pooled analysis from four clinical tri...
7. Peter Hillmen et al. ASH 2023 abstract Oral 631. 8. ClinicalTrials gov. NCT04608318. Available at: https://www.clinicaltrials.gov/ct2/show/NCT04608318 (accessed August 2021). 9. DCLLSG. CLL17 Trial. Available ...
None of the 2223 subjects had liver progression at post-BL TPs.Conclusions:Based on the data analysis of a large sample size, it is evident that assessment of liver enlargement as a group A parameter in CLL clinical trials, does not impact the ORA. Liver is rarely even assessed as ...
[6]. National Cancer Institute. Chronic Lymphocytic Leukemia Treatment (PDQ®)–Patient Version.https://www.cancer.gov/types/leukemia/patient/cll-treatment-pdq. AccessedMay 2022. [7]. ClinicalTrials.gov. ELEVATE CLL TN: Study of Obinutuzumab + Chlorambucil, Acalabrutinib (ACP-196) + Obinutuzum...
研究人员在 3 期 CLL12 试验(ClinicalTrials.gov 标识符:NCT02863718)中比较了依鲁替尼与安慰剂。该试验招募了无症状、未接受过治疗、比奈 A 期 CLL 的患者,这些患者的进展风险增加。 患者被随机分配接受每天 420 毫克剂量的依鲁替尼(182 名患者)或安慰剂(181 名患者)。治疗组之间的基线特征平衡良好。总体而言...
In October 2022, KM visited her PCP for her annual checkup. She reported having persistent fatigue and recent occurrences of night sweats. Clinical Workup and Diagnosis: WBC: 186,000; 80% lymphocytes Hgb, 9.4 g/dL Platelets, 85 x 109/L ECOG PS 0 Elevated serum beta-2-microglobulin Flow...
In clinical trials, major hemorrhage occurred in 7% of patients taking CALQUENCE without antithrombotic agents and 4% of patients taking CALQUENCE with antithrombotic agents. Consider the risks and benefits of antithrombotic agents when co-administered with CALQUENCE. Monitor patients for signs of ...
5 Cancer Clinical Trials You May Have Missed Brielle Benyon December 19th 2021 There are many cancer clinical trials that patients can enroll in across the United States. Here is a snapshot of some of the more recent ones. Calquence Remains Effective and Safe After 3 Years Compared With Standa...
临床试验正在美国各地进行。NCI支持的临床试验相关信息可在NCI临床试验搜索网页上找到。其他组织支持的临床试验可以在ClinicalTrials.gov网站上找到。 可能需要进行定期检查(随访)。 一些用于癌症的诊断或疾病分期判定的检查会反复进行。用于确认治疗效果的检查也会反复进行。根据这些检查的结果来判断是否继续、改变、停止治疗...