Furthermore, if the immunogen contains contaminants of a highly immunogenic nature, large amounts of irrelevant antibody will be generated and which must subsequently be absorbed. The unpredictable nature of heteroantisera can be overcome by adopting the monoclonal antibody technique which allows one to...
The unpredictable nature of heteroantisera can be overcome by adopting the monoclonal antibody technique which allows one to produce standardized antibody with well defined and selected specificity toward a given epitope on a macromolecule. Cross-reactions are not eliminated by monoclonal antibodies. ...
Monoclonal antibodies are produced by the cell fusion method, whereby immune murine spleen cells are fused with a murine myeloma to produce large quantities of specific homogenous antibodies. These have obvious advantages over conventional antisera particularly for in vitro diagnostic procedures. The use ...
Therapies against HER3 under clinical development. Monoclonals antibodies (mAbs), bispecific antibodies (bAbs), antibody–drug conjugate (ADC) and other therapies such as HER3 vaccine Full size image Fig. 3 Cancers in which have been reported clinical efficacy of anti-HER3 drugs under clinical de...
aToday monoclonal antibodies are widely used in cancer therapy. However, clinical experience as well as translational research into antibodies\' pharmacology and effector mechanisms has identified limitations of antibody therapy, including inefficient effector cell recruitment or initiation of complement-...
Molecularly targeted cancer therapies, such as small-molecule kinase inhibitors and monoclonal antibodies, constitute a rapidly growing and an important part of the oncology armamentarium. Unlike conventional (cytotoxic) chemotherapeutics, targeted therapies were designed to disrupt cancer cell pathogenesis at...
V. et al. Epitope mapping of the hemagglutinin molecule of a highly pathogenic H5N1 influenza virus by using monoclonal antibodies. J. Virol. 81, 12911–12917 (2007). Article CAS PubMed PubMed Central Google Scholar Franco, S. et al. Detection of a sexually transmitted hepatitis C virus ...
or as combination therapies with antibodies, priming agents, and other drugs. This review summarizes the recent clinical status of allogeneic NK cell-based therapies for the treatment of hematological and solid tumors, discussing the main characteristics of the different cell sources used for NK produc...
Human epidermal growth factor receptor 2–positive (HER2+) breast cancer accounts for ~25% of breast cancer cases. Monoclonal antibodies (mAbs) against HER2 have led to unparalleled clinical benefit for a subset of patients with HER2+ breast cancer. In t
In the era of precision medicine, it has been increasingly recognized that individuals with a certain disease are complex and different from each other. Due to the underestimation of the significant heterogeneity across participants in traditional “one-