Published data for phase 3 trials in ovarian cancer (JAVELIN 100 and 200, ATALANTE, IMAGYN 050) report response per RECIST 1.120,35,36, and furthermore, PFS determined by irRECIST has not shown improved predictive value for OS compared with PFS by RECIST 1.134. Studies evaluating different ...
2.2 On-going clinical trials A lot of clinical trials have proliferated since the beginning of COVID-19 pandemic to slow its spread. All the on-going clinical trials are registered either in ClinicalTrials.gov or the International Clinical Trials Registry Platform (ICTRP) of the WHO. Most of ...
7 A pooled analysis of phases I and IIa concluded that the heterologous scheme was safe, well tolerated, and elicited the highest immune response, with a mixed Th1/Th2 profile.6 Here, we report immunogenicity, safety, and reactogenicity of two doses of SOBERANA 02 and the heterologous ...
The trial period is divided into two phases, and each phase consists of seven weeks with a washout period of seven days between the phases (Figure 1). The volunteers are randomly allocated into two groups. In each study leg, the participants are submitted to treatment with one of the two ...
Phases of stroke during the intervention For stroke patients at different stages, the effect of MI combined with NIBS seems to be different. For example, when compared with single therapy, MI combined with NIBS therapy is more effective at improving the FMA-UE score in the acute and subacute ...
The intervention programme is divided in two phases: the intensive phase, which lasts 20 hours distributed along one month (Table 1); and the follow up phase. The results of Phase 1 of the current study will determine the periodicity and other components (described in the phase 1) of the ...
We correlated the type of mutation, resulting in residual dysferlin protein versus total loss of dysferlin protein, assessed by Western Blot and mutation prediction (Figure 1), with outcomes during both treatment phases. We found in both sequences, more pronounced in the placebo-deflazacort sequence...
Trial Registration ClinicalTrials.gov Identifier: NCT03998436; Clinical Trial Registry, India CRI Number: CTRI/2018/11/016295 Introduction Diabetic foot ulcers (DFUs) are common severe complications of diabetes that substantially contribute to morbidity and mortality. The prevalence of DFUs is reported ...
An assistant unknown to the next phases of the study randomly assigned a number to each participating subject. In a second moment, the sequence of numbers obtained was randomized into two groups: an LDT group and a DT group. This assistant was the person in charge of giving appointments for...
we mean the way in which decision support systems interact (or choose not to interact) with other related systems, such ascomputerized physician order entry(CPOE) andelectronic health record(EHR) systems. Based on our review, we have formulated a model with four distinct architectural phases for...