“In a clinical trial, participants receive specific interventions according to the research plan or protocol created by the investigators. Clinical trials may compare a new medical approach to a standard one that is already available, to a placebo that contains no active ingredients, or to no int...
Clinical trials are broken down into phases, with each phase having a different purpose within the trial. Phase I trials involve a small group of people (20-80) and are concerned with determining a safe dose of the drug being studied as well as its potential side effects. In Phase II, t...
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Scientists first test these new treatments with laboratory experiments. Next, they try them on laboratory animals. Only when they deem them safe and useful enough in these early stages does a clinical trial start on people -- first in small groups and then in larger ones. Clinical trials help...
Sci. 2011, 12, 5592-5603; doi:10.3390/ijms12095592 Review OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 www.mdpi.com/journal/ijms Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises? Derliz Mereles 1,* and Werner Hunstein 2 1 Department ...
(IMUs) set up at the Outram and Kent Ridge campuses in 2009. The IMU at Outram campus is the largest public early-phase clinical research unit and is funded with S$20 million over five years by the Singapore Ministry of Health. It has already hosted more than 20 clinical trials, with ...
Decitabine is well tolerated and although the most significant effects have been observed in hematologic malignancies, it also displays a good activity against solid tumors. Different Phase I/II clinical trials are currently underway, including co-administration studies with HDACi for patients with advan...
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Phase IVclinical trials, also called post-marketing studies, are conducted after a treatment has been approved. The purpose of these trials is to provide an opportunity to learn more details about the treatment and to address questions that may have come up during other phases of trials. This ...
Phase 2 Trials After appropriate dosing is established in Phase 1, the clinical trial moves on to Phase 2. In this phase, the experimental drug or treatment is tested on a larger group of people (up to several hundred), to see if it’s effective and safe. If results from this phase ...