Longitudinal research and clinical trials for PSP are ongoing and require reliable measures that are sensitive to disease progression. Despite susceptibility to subjective limitations, clinical and cognitive assessments are the most used instruments in therapeutic trials in PSP. The objective of this ...
Assessing the impact of COVID-19 on registered interventional clinical trials This figure depicts the method of using a Fourier series fit of pre-coronavirus disease (COVID) data to correct for seasonality. Reimagining the peer-review system for translational health science journals ...
Reimagining the peer-review system for translational health science journals Phases of the collaborative review process model. Browse Articles Recently Published Most Cited Open access Surfing the T Wave: A Primer on ECG T Wave Morphologies Encountered in Clinical Trials and Impact on the QT Interval...
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basket trials pay more attention to the commonalities of targets in pan-cancer. The off-label attempt of basket trials brings hope to patients faced with the treatment dilemma. In addition, basket trials may provide initial proof-of-principle evidence for the clinical treatment potential of newly ...
A majority of tau immunotherapy clinical trials are enrolling patients with AD or have advanced to include such patients. However, more recently trials have been initiated on patients with primary tauopathies, mostly on the most common one, progressive supranuclear palsy (PSP), but lately ...
The Clinical Trials reported in this issue are: PHASE I: CuraGen, TopoTarget Begin Study of HDAC Inhibitor Candidate as Combination Therapy for Soft Tissue Sarcomas Ambrilia%u2019s Therapeutic Peptide Shows Clinical Activity in Metastatic Prostate Cancer Patients PHASE II: Alchemia%u2019s Precursory ...
combined meta-analysis of 5 randomized controlled trials. Any benefits from prostate cancer screening may take greater than 10 years to accrue; therefore, men who have a life expectancy of less than 10 to 15 years should be informed that screening for prostate cancer is not beneficial and has ...
Proteomic biomarker-driven clinical trials. Employing personalized therapy signatures, designing clinical trials based on proteomic biomarkers enhances the likelihood of participant response to experimental therapy. Stratifying patients into subgroups for tailored treatment approaches using proteomic data is essent...
Clinical Pharmacology & Therapeutics is a cross-disciplinary clinical medicine journal publishing advances in the nature, action, efficacy, and evaluation of therapeutics.