M. GranerMadsen H, Hellwinkel JE, Graner MW. Clinical trials in glioblastoma -- designs and challenges. In: Lichtor T, editor. Molecular consid- erations and evolving surgical management issues in the treatment of patien...
For instance, in the recently published TARGET study (registered in NIHR Central Portfolio Management System under the reference CPMS ID 39172), the primary aim was to match advanced stage patients to early phase clinical trials on the basis of plasma ctDNA analysis of both somatic mutations and...
Background: Glioblastoma is the most common primary malignant brain tumor in adults, but effective therapies are lacking. With the scarcity of positive phase III trials, which are increasing in cost, we examined the ability of positive phase II trials to predict statistically significant improvement ...
This review aims to elucidate the advancements in the clinical applications of mRNAs for addressing significant health-related challenges such as cancer, autoimmune diseases, genetic disorders, and infections and provide insights into the efficacy and safety of mRNA therapeutics in recent clinical trials....
Liquid biopsy has been introduced as a new diagnostic concept predicated on the analysis of circulating tumour cells (CTCs) or circulating tumour-derived factors, in particular, cell-free tumour DNA (ctDNA). Highly sensitive liquid biopsy assays have bee
currently in clinical trials for different solid malignancies Table2. In contrast, there are, as yet, no approved epi-drugs for CVDs, however, more than twenty Phase 3–4 randomized trials are currently ongoing to evaluate the epigenetic efficacy of the so-called “repurposed” drugs against ...
The purpose of early stage clinical trials is to determine the recommended dose and toxicity profile of an investigational agent or multi-drug combination. Molecularly targeted agents (MTAs) and immunotherapies have distinct toxicities from chemotherapies that are often not dose dependent and can lead...
et al. selective delivery of boron by the melanin precursor analogue p-boronophenylalanine to tumors other than melanoma. cancer res. 1990;50(1):138–41. cas pubmed google scholar coderre ja, elowitz eh, chadha m, et al. boron neutron capture therapy for glioblastoma multiforme using p-boro...
The first large phase III trial of ipilimumab (a CTLA-4 inhibitor) plus nivolumab (a PD-1 inhibitor) in recurrent World Health Organization (WHO) grade IV glioma (glioblastoma) (NCT02017717) was initiated in 2014. With so many clinical trials, a comprehensive analysis of CTLA-4 expression ...
for GFAP, which suggests glial progenitors were included in the grafted cells with DAPs. The DAPs became mature DA neurons that produced dopamine and improved the abnormal behaviors of 6-OHDA-lesioned rats. Two previous clinical trials for PD using PSCs have transplanted ESC-derived neural ...