Epigenetic editing, currently in clinical trial to silence MYC in hepatocellular carcinoma, thus facilitates targeted inquiry into the functions of genes in the pathophysiological mechanisms. Altogether, epigenetic editing will contribute to augmenting the efficacy of precision medicine....
heat-inactivated PG or stimulation with FimA to had no effect on IL-6 production induced by TNFα. RNA-seq analysis revealed that PG pre-infection affects only a small number of TNFα-regulated genes, suggesting possible gene-specific epigenetic mechanisms. Surprisingly, analysis of global DNA me...
Effect of Ubrogepant vs Placebo on Pain and the Most Bothersome Associated Symptom in the Acute Treatment of MigraineThe ACHIEVE II Randomized Clinical Trial Richard B. Lipton, MD1; David W. Dodick, MD2; Jessica Ailani, MD3; et al Kaifeng Lu, PhD4; Michelle Finnegan, MPH4; Armin Szegedi...
Ishwaran H, Kogalur UB, Chen X, et al. Random survival forests for highdimensional data. Stat Anal Data Min. 2011. https://doi.org/10.1002/sam.10103. Article Google Scholar Foster JC, Taylor JM, Ruberg SJ. Subgroup identification from randomized clinical trial data. Stat Med. 2011. htt...
In regard to liver diseases, MSCs have been used to treat cirrhosis in a limited number of patients. In a phase I trial, four patients with decompensated liver cirrhosis were included. They received autologous MSC infusion through a peripheral vein. There were no side-effects in the patients ...
Epratuzumab-cys-tesirine is currently under evaluation in a phase I/II clinical trial in patients with R/R ALL (NCT03698552) [154]. CD25 CD25, α-chain of the interleukin-2 (IL-2) receptor, is a type I transmembrane protein, expressed on activated and regulatory T cells, activated B ...
In a double-dummy controlled trial, effects of Echinacea spray in combination with sage were compared to chlorohexidin/lidocain combination on sore throat. Interestingly, 60% of patients in each group became symptom-free after three days with no significant difference between these two combinations...
Efficacy of Ivermectin Treatment on Disease Progression Among Adults With Mild to Moderate COVID-19 and ComorbiditiesThe I-TECH Randomized Clinical Trial Steven Chee Loon Lim, MRCP1; Chee Peng Hor, MSc2,3; Kim Heng Tay, MRCP4; et al Anilawati Mat Jelani, MMed5; Wen Hao Tan, MMed6; Ho...
However, most peer-reviewed reports of ML use in this capacity focus on preclinical research and development rather than clinical trial planning. This may be due to the greater availability of suitable large, highly dimensional datasets in translational settings in addition to greater potential costs,...
Previously, anti-GD2 immunotherapy was combined with IL-2. However, this was discontinued, since a recent randomized phase III trial of patients with high-risk neuroblastoma showed that the addition of IL-2 to anti-GD2 antibody therapy did not improve outcome and increased treatment toxicity [8]...