The Phase 2 studies are randomized, double-blind, placebo-controlled trials that will evaluate multiple doses of VX-548 in patients with acute pain following bunionectomy surgery or abdominoplasty surgery. Both studies will also include a hydrocodone bitartrate /acetaminophen reference arm. The primar...
Anticancer drug development is a costly and protracted activity, and failure at late phases of clinical testing is common. We have previously proposed the Pharmacological Audit Trail (PhAT) intended to improve the efficiency of drug development, with a f
et al. Final report of a phase I trial of olaparib with cetuximab and radiation for heavy smoker patients with locally advanced head and neck cancer. Clin. Cancer Res. 24, 4949–4959 (2018). Article CAS PubMed PubMed Central Google Scholar Loap, P. et al. Combination of olaparib and ...
In early 2024, Vertex will release results from a pair of placebo-controlled studies and a third, single-arm trial, in different forms of acute pain. Late-stage studies in chronic pain are following. The financial implications for Vertex are enormous, with some analysts estimating VX-548 could...
The single-dose mRNA vaccine administered to expectant mothers could be ready for a fall surge of RSV in the United States.Continue Reading By Hayden Schmidt Feature15 Feb 2023 Developing Clinical Trial Budgets, Considerations, and Best Practices ...
In GBM patients, multiple DNA vaccine clinical trials have been initiated and completed. One example for a tumor-associated antigen specific DNA vaccine, which has been tested in a phase 1 clinical trial in patients with operable recurrent GBM, is the VXM01 pilot study. This study investigated ...
H. et al. Anti-angiogenic activity of VXM01, an oral T-cell vaccine against VEGF receptor 2, in patients with advanced pancreatic cancer: a randomized, placebo-controlled, phase 1 trial. Oncoimmunology 4, e1001217 (2015). Article PubMed PubMed Central Google Scholar Kavan, P., Saltzman,...
Accumulating evidence has shown that a DNA double-strand break(DSB) is typically the most harmful type of DNA damage, and that it compromises genome stability.70In mammalian cells, a number of vital DNA repair functions and processes against various DNA damage have evolved. For example, the mis...
In GBM patients, multiple DNA vaccine clinical trials have been initiated and completed. One example for a tumor-associated antigen specific DNA vaccine, which has been tested in a phase 1 clinical trial in patients with operable recurrent GBM, is the VXM01 pilot study. This study investigated ...
Randomized controlled trial of screening for hepatocellular carcinoma. J. Cancer Res. Clin. Oncol. 2004, 130, 417–422. [CrossRef] J. Clin. Med. 2020, 9, 3843 12 of 21 7. Marrero, J.A.; Kulik, L.M.; Sirlin, C.B.; Zhu, A.X.; Finn, R.S.; Abecassis, M.; Roberts, L.R...