Electrolyte disturbances (e.g., hypokalemia ) Diabetes Drugs (e.g., theophylline , adenosine , digoxin ) Surgery (e.g., coronary artery bypass grafting, valvular repair) Hypertension Hyperthyroidism Hypothermia Pulmonary causes: chronic obstructive pulmonary disease ( COPD ), pulmonary embolism ...
cardiac events or dysfunction (eg, known prolonged Q-T interval, clinically significant hypokalemia, clinically unstable cardiac disease, complete left bundle branch block), and having significant hepatic disease (eg, known acute hepatitis, history of cirrhosis, manifestation of end-stage liver disease)...
Important observations of this syndrome include fever, abdominal pain, diarrhea, shock, and variable presence of rash, conjunctivitis, extremity edema, mucous membrane changes [30], cheilitis and adenitis [31]. Inflammation to myocardial injury, shock and development of coronary artery dilatation or an...
When change does occur it is often in the form of diarrhea, particularly if the tumor has a large villous component. These patients may have hypokalemia, as shown in laboratory studies. Some patients experience a change in the caliber of the stool. Large tumors can cause obstructive symptoms....
The common clinical scenarios in which the possibility of primary aldosteronism should be considered include the following: Patients with spontaneous or unprovoked hypokalemia in the setting of hypertension [18] Patients who develop severe and/or persistent hypokalemia in the setting of low to ...
Vasoocclusion (microvascular occlusion): multiple pathophysiologic mechanisms, only partially related to the number of irreversibly sickled cells; other factors include: The tendency of sickled RBCs to adhere to and activate vascular endothelium , which exposes subendothelial matrix proteins (e.g., ...
Hypokalemia, usually mild, is a well-known AE associated with fosfomycin.6,8 The fosfomycin dose used in our study was chosen based on pharmacodynamic data,24 allowing a 90% probability of target attainment for bactericidal effect for an MIC of 32 mg/L or less.15 However, selection of ...
The most common non-hematological grade 3 adverse events were fever (9 [43 %] of 21 patients), hypokalemia (9 [43 %] of 21 patients), fever and neutropenia (8 [38 %] of 21 patients), and cytokine release syndrome (3 [14 %) of 21 patients). The authors concluded that CD19-CAR ...
5 Short-term, small randomized clinical trials6,7 showed only nominal differences in safety issues such as hypokalemia, but the observational study5 showed a worse safety profile for chlorthalidone with higher rates of hypokalemia and hyponatremia. Both indirect network meta-analyses and traditional ...
Common electrolyte derangements found in COVID-19 include hyponatremia (20.4–50%) and hypokalemia (15.1–62%), with most exhibiting mild depletion (Na 130–135 mmol/L, K 3.0–3.5 mmol/L) [53,[156], [157], [158], [159]]. Lower sodium levels have been associated with more severe ...