Associated signs Aggression as a presenting problem may be the result of organic disease, particularly disorders affecting the brain. In these patients the onset of aggressive behavior is usually acute and may be associated with other neurologic signs suggesting cerebral dysfunction (e.g., seizures an...
Sickle cell disease ( SCD ) is a group of genetic disorders that cause an abnormal Hb molecule ( Hb S) that transforms RBCs into sickle-shaped cells, resulting in chronic anemia , vasoocclusive episodes, pain , and organ damage. Epidemiology[2] Most common form of intrinsic hemolytic anemia...
Safe administration of doxycycline to this population has been documented if the course is ≤ 21 days. Lyme disease treatment: Doxycycline is recommended for acute neurologic disease owing to its efficacy. For other stages, beta-lactam antibiotics are preferred. Post-Lyme disease syndrome (PLDS) ...
Owing to the general presence of strong anti-A alloantibodies in type B cats, type A blood given to a type B cat results in life-threatening acute hemolytic transfusion reactions. Immediate withdrawal of a transfusion and supportive care may save a patient. Other transfusion reactions, unrelated...
Drug allergy encompasses a spectrum of immunologically-mediated hypersensitivity reactions (HSRs) with varying mechanisms and clinical presentations. This type of adverse drug reaction (ADR) not only affects patient quality of life, but may also lead to
Drug allergy encompasses a spectrum of immunologically-mediated hypersensitivity reactions (HSRs) with varying mechanisms and clinical presentations. This type of adverse drug reaction (ADR) not only affects patient quality of life, but may also lead to
Monitor patients closely for symptoms and signs that may be clinical manifestations of underlying immune-mediated adverse reactions. Early identification and management are essential to ensure safe use of anti–PD-1/PD-L1 treatments. Evaluate liver enzymes, creatinine, and thyroid functio...
Current practices vary widely regarding the immunological work-up and management of patients affected with defects in thymic development (DTD), which inclu
CMV may produce a mononucleosis syndrome similar to that caused by Epstein-Barr virus (EBV), primary toxoplasmosis, or acute HIV seroconversion. In a large study of 494 patients with infectious mononucleosis, 79% of cases were due to EBV, and, in the 73 heterophile antibody–negative patients...
Willi, et al., “Identification, Molecular Characterization, and Experimental Transmission of a New Hemoplasma Isolate from a Cat with Hemolytic anemia in Switzerland”, Journal of Clinical Microbiology, vol. 43, No. 6, p. 2581-2585, 2005. Inokuma, et al., “Molecular Survey of Mycoplasma ...