Phosphodiesterase 5 inhibitor mirodenafil ameliorates Alzheimer-like pathology and symptoms by multimodal actions. Alzheimers Res Ther. 2022;14(1):92. Article CAS PubMed PubMed Central Google Scholar Cummings J, Lee G, Nahed P, Kambar MEZN, Zhong K, Fonseca J, et al. Alzheimer’s disease ...
Turnidge, MD SA Pathology at Women's and Children's Hospital North Adelaide, Australia Melvin P. Weinstein, MD Robert Wood Johnson Medical School New Brunswick, New Jersey, USA Barbara L. Zimmer, PhD Siemens Healthcare Diagnostics Inc. West Sacramento, California, USA Acknowledgment CLSI and the...
near the target mutation site, using the web tool Silent Mutator (https://molbiotools.com/silentmutator.php) [54] and the DNAStar Lasergene software (v.7.1, DNAstar). Two of these silent mutations were introduce to create a new restriction site for the Ssp1 enzyme (Thermo Fisher...
The human genome project was a ground-breaking scientific endeavour that not only gave us a near complete map of our genetic code but also paved the way for new innovative sequencing technologies and computational methods that have enabled the clinical application of genomics [1,2,3,4]. While ...
Nebulization of low-dose aspirin ameliorates Huntington’s pathology in N171-82Q transgenic mice Miscellaneous Virology, pathogenesis, epidemiology and clinical management of HTLV-1 infection. Proceedings of the 30th HTLV European research network (HERN 2023) Subjects...
et al. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet. Med. 17, 405–424 (2015). PubMed PubMed Central Google Scholar Lek, M. et...
The American journal of pathology. 1997, 151 (6): 1587-1600. PubMed Central CAS PubMed Google Scholar Riminucci M, Liu B, Corsi A, Shenker A, Spiegel AM, Robey PG, Bianco P: The histopathology of fibrous dysplasia of bone in patients with activating mutations of the Gs alpha gene: ...
The reconceptualization of Alzheimer’s disease (AD) as a clinical and biological construct has facilitated the development of biomarker-guided, pathway-based targeted therapies, many of which have reached late-stage development with the near-term potential to enter global clinical practice. These medic...
a large-scale whole-exome sequencing study has identified suggestive rare variant enrichment inGRNin LOAD [202]; interestingly, one such patient had definite AD pathology, indicating thatGRNvariation associated with clinical AD may not always be due to underlying FTLD pathology [202]. An additional...
These studies show long-term survival of the human cells within the heavily plaque-laden brain and suggest that Aβ plaques are not toxic to the transplanted cells and that the therapeutic actions of these human cells may occur despite this pathology (G Carlson, personal communication). The ...