Dopamine D2 and D3 receptor occupancy in normal humans treated with the antipsychotic drug aripiprazole (OPC 14597): a study using positron emission tomography and [11C] raclopride. Neuropsychopharmacol. 2002;27:248–59. CAS Google Scholar McGavin JK, Goa KL. Aripiprazole. CNS Drugs. 2002;...
cell supernatant containing the leukocyte fraction was discarded and the culture was rinsed thrice with RPMI-1640 GlutaMAX containing 1% penicillin/streptomycin. The remaining adherent monocytes were flushed several
Delamanid (10; OPC-67683) is being evaluated by Otsuka Pharmaceutical Co. (Tokyo, Japan) in a phase-III trial for the treatment of MDR TB in combination with other TB drugs over 6 months (NCT01424670). Otsuka has filed an MAA with the EMA in 2011 and a Pharmaceuticals and Medical Devic...
cell supernatant containing the leukocyte fraction was discarded and the culture was rinsed thrice with RPMI-1640 GlutaMAX containing 1% penicillin/streptomycin. The remaining adherent monocytes were flushed several
(9b), which is active against various Gram-positive bacteria including linezolid-resistant strains.95 Like linezolid, tedizolid (9b) binds to the 50S ribosome preventing the formation of the 70S initiation complex, which in turn blocks the initiation of protein synthesis.96 Delamanid (10; OPC-...
TOKYO -- (BUSINESS WIRE) -- Otsuka Pharmaceutical Co., Ltd. (OPC) today announced that the clinical trial results for tolvaptan, an investigational drug for the treatment of ADPKD, were presented for the first time at the American Society of Nephrology annual meeting and simultaneously published...
The first-in-patient clinical trial on neurologic disease was conducted on SCI patients [50]. Oligodendrocyte progenitor cells (LCTOPC1), which are also nomenclature as AST-OPC1 or GRNOPC1, is the world's first hESC-derived therapy, and the phase 1 trial was approved by US-FDA in 2009...
Spontaneous remyelination by OPCs at the injury site after SCI is limited and transplantation of exogenous cells is more effective in improving outcomes [98]. In animal SCI models, OPC cell transplantation has showed evidence of remyelination and functional recovery [119, 120]. An initial study ...
Lovastatin, a drug that presented a mean value of ER = 1.23 ± 0.1 but with a demonstrated activity on OPC differentiation and myelin formation23,24 was added to this list to provide a con- venient internal control for the screening. Moreover, statins are in an ...
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