Spectrum of clinical manifestations of SLE patients from India and its correlation with KIR gene polymorphismSLEANAAnti-dsDNA antibodiesSLEDAIKIRNK cellQuite a few of the genes of the KIR, which are not uncommon in Indian population are also significantly associated with SLE in Indian patients. Few...
associated with the main clinical manifestations of SLE, and sorted out the potential reasons for the differences in susceptibility in Asia and Europe. Moreover, the therapies targeting STAT4 and IRF5 were also evaluated in order to propose more personalized and targeted treatment plans in SLE. Ac...
features in systemic lupus erythematosus (SLE)–affected sibpairs, and to estimate correlations with the age at SLE diagnosis in affected sibpairs and parent–offspring pairs.MethodsConcordance rates and sibling risk ratios were used as indicators of familiality for 15 manifestations of SLE. Pearson...
Almost half of SLE patients develop renal disease [19], and this has a direct impact on morbidity and mortality [20]. Renal manifestations frequency in our series was similar with all compared Arab studies (Table3). Neurological manifestations were less frequent than other clinical characteristics ...
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Our aim was to discover genetic loci within the MHC region that are associated with specific clinical and/or immunological manifestations within SLE cases and hence to find evidence of genetic variants that may drive specific forms of the disease. For complex heterogeneous diseases such as SLE, ...
Anti-Ro antibody and clinical manifestations: lessons from systemic lupus erythematosus in the elderlyAnkylosing spondylitisLei gong tengTripterygium wilfordii Hook fDear Editor, As we know, previous studies have shown the association of systemic lupus erythematosus (SLE) and anti-Ro antibody with a ...
We analysed the prevalence of clinical manifestations and immunological parameters in 194 patients with SLE and classified them in subgroups according to age at onset, gender and type of antibodies: we detected significant differences in the various subgroups.In SLE that initiated before the age of ...
formation, which may induce or directly damage multiple organs. This study was carried out aiming to quantify certain T lymphocyte subsets (CD3 + , CD4 + , and CD8 + ) in SLE patients and to elucidate if there is a possible influence of disease activity scores and clinical manifestations. ...
The mechanisms that drive the diverse disease manifestations and increased cancer risk associated with systemic sclerosis are unclear. Investigating the genomic alterations observed in patients with systemic sclerosis could contribute towards untangling this complex disease. Carol M. Artlett & John Varga ...