BackgroundStandard therapy of advanced non–small-cell lung cancer harboring an activating mutation in the epidermal growth factor receptor (EGFR) gene is treatment with tyrosine kinase inhibitors (TKI). However, for rare and compound mutations of the EGFR gene, the clinical evidence of TKI therapy...
Clinical Lung Canceris a peer-reviewed bimonthly journal that publishes original articles describing various aspects of clinical and translational research oflung cancer.Clinical Lung Canceris devoted to articles ondetection,diagnosis,prevention, andtreatmentof lung cancer. The main … ...
Lung cancer (LC) is an important comorbidity of interstitial lung disease (ILD) and has a poor prognosis. The clinical characteristics and outcome of each ILD subtype in LC patients have not been sufficiently investigated. Therefore, this study aimed to evaluate the difference between idiopathic pul...
ROS1-rearranged lung cancers benefit from first-line crizotinib therapy; however, clinical and molecular factors that could affect crizotinib efficacy in ROS1-rearranged lung cancers are not yet well-elucidated. Our retrospective study aimed to compare t
Advanced non-small-cell lung cancer (NSCLC) patients with EGFR T790M-positive tumours benefit from osimertinib, an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI). Here we show that the size of the EGFR T790M-positive clone impacts response to osimertinib. T790M subclonality,...
et al. Clinical impact of variability on CT radiomics and suggestions for suitable feature selection: a focus on lung cancer. Cancer Imaging 19, 54 (2019). https://doi.org/10.1186/s40644-019-0239-z Download citation Received09 April 2019 Accepted16 July 2019 Published26 July 2019 DOIhttps:...
Tumour cells in the tumour draining vein of patients with non-small cell lung cancer: detection rate and clinical significance =0.019) and multivariate regression analysis demonstrated an independently significant (=0.004) prognostic impact. Conclusion: The present study shows that......
The role of peroxiredoxins in cancer (Review) Arianna Nicolussi, Sonia D'inzeo, Carlo Capalbo, Giuseppe Giannini, Anna Coppa Pages:139-153Published online on: 10 一月 2017 Prognostic significance of preoperative mean platelet volume in resected non-small‑cell lung cancer ...
Analysis of a large cohort of EGFR-mutant lung cancer cell-free DNA samples along with longitudinal samples from a patient with EGFR-mutant lung cancer identifies pathways that inhibit EGFR-inhibitor response. Co-occurring genetic alterations influence c
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