Hydroxyurea is a highly effective treatment for SCD but less so for -thalassemia, and does not represent curative therapy. As technology and use of cellular and gene therapies expand, SCD and thalassemia should be among the highest disease priorities....
Stem cell transplantation for thalassemia major Clinical features and natural history of thalassemia Recent estimates suggest that worldwide more than 120,000 children with thalassemia are born annually.1 The highest prevalence is in families who live in or originate from the Indian subcontinent and ...
Clinical features and molecular analysis of the alpha thalassemia/mental retardation syndromes. II. Cases without detectable abnormality of the alpha globi... Medwin D, MacGillivray MH, Weatherall DJ, Higgs DR (1990 b ) Clinical features and molecular analysis of the α thalassemia/mental retardatio...
Quantitative analysis of red blood cell (RBC) shapes was performed in 79 patients with beta-thalassemia/HbE disease, using scanning electron microscopy (SEM). Most patients had many abnormal RBC shapes, namely: torocytes, codocytes, dacryocytes, keratocytes, and schizocytes with a reduction ...
The importance of the genetic picture and globin synthesis in determining the clinical and hematological features of thalassemia intermedia. Br J Hematol 1979; 41: 211-221.Gallo E, Massaro P, Miniero R, et al. The importance of the genetic picture and globin synthesis in determining the ...
The geometric mean 卤 standard error of the mean was 31... GE Cartwright,CM Huguley - 《American Journal of Medicine》 被引量: 208发表: 1948年 Clinical, hematological and genetic features of sickle-cell anemia and sickle cell-β thalassemia in a Brazilian population Clinical, hematological and...
Clinical Features and Molecular Analysis of Hb H Disease in Taiwan Thalassemia is highly prevalent in Taiwan, but limited data are available about the association between genotypes and clinical manifestations in Taiwanese patients with Hb H disease. Here, we studied α-globin gene abnormalities and cl...
A prospective cohort study was conducted to estimate the incidence rate and to identify the serotype and clinical features of HFMD among children in northern Thailand. A validated questionnaire and throat swab were used for data collection. Polymerase chain reaction (PCR) was used to detect human ...
Integration of molecular data with histologic, radiologic, and clinical features is imperative for accurate diagnosis of pediatric central nervous system (CNS) tumors. Whole transcriptome RNA sequencing (RNAseq), a genome-wide and non-targeted approach, allows for the detection of novel or rare oncog...
β-Thalassemia is the most common single gene disorder in Iran and more than 25,000 affected individuals have been reported. It has been reported that in patients with β-thalassemia in the presence of Xmn1 polymorphic site the level of Hb F and Gγ: Aγ ratio is increased. The prevalence...