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The MDD used for the calculations are listed in Online Resource Table 1. Table 1 Patient sociodemographic characteristics with respect to sex Full size table Statistical analysis Descriptive data analysis was performed using SPSS Statistics (version 25, IBM Corp., Armonk, NY, USA) and R (version...
Good Publication Practice 3 HbA1c: Haemoglobin A1c HCP: Healthcare professional HIV: Human immunodeficiency virus IEC: Independent ethics committee IM: Intramuscular IMP: Investigational medicinal product IR: Immediate release IRB: Institutional review board LAR: Long-acting release M: Mont...
Sample size determination was performed using G*Power 3.1.9 for a global F test between the 4 groups with 5 repeated measurements in each group. Estimates used in the calculations are based on our previously collected WISCI-II scores and published results on longitudinal scores [28, 29]. We...
Through careful risk score calculations, it is possible to prognosticate type 2 diabetes, enabling timely interventions and improving clinical outcomes [10]. PRS can develop a preventive care approach when combined with clinical risk scores. Studies have reported that it is helpful in gestational risk...
Other considerations include the specification of both test and control treatments, an outcome measure for evaluating the treatments, a bias-free method for assigning patients to treatment groups, and calculation of the necessary sample size.86Sample size calculations are affected by the number of trea...
The cost effectiveness ratio (CER) for extended life expectancy per 100,000 elderly 65 years of age and over, calculations have shown that combined vaccinations with influenza vaccine and PPV would reduce costs in comparison with vaccination with influenza vaccine alone (Level III) [108]. Further...
As this is a three-arm trial, the final number of control cases in sub-group analyses will be twice those assumed in these calculations. A medium intervention effect (f2 = 0.15) is detectable at 80% power and α = 0.05 with 55 participants, in a two-arm trial (27.5 in each arm), ...
neuropsychiatric outcomes. As there was not a pre-specified hypothesis for treatment effect relative to placebo, no formal sample size calculations were performed but, based on prior experience with use of similar cognitive test battery in a prior DLB clinical trial31, 40 participants per arm was ...