BTX-1188 is an MGD which targets GSPT1 and IKZF1/3 for dual degradation in the therapy of solid tumors and AML. Within the realm of hematologic malignancies treatments, BTX-1188 demonstrates a number of distinguishing characteristics. One is that it targets GSPT1 and IKZF1 to achieve dual ...
An interesting property of mechanistic models is that, in addition to study molecular mechanisms of disease in a particular condition, they can be used to predict the potential consequences that perturbations (mutations or changes in the expression) of the proteins that compose the pathway can have ...