Director of Stroke, Dementia and Heart Disease Laboratory, Western University, London, Ontario, Canada Learn More Professor Dario Alessi, FRS, FMedSci, FRSE Director of MRC Protein Phosphorylation & Ubiquitylation Unit, University of Dundee, UK ...
Immuno-oncology has proven to be a field with untapped potential in the fight against cancer. Many clinical trials are currently testing different ways to program the body’s immune system to target and eliminate tumors. Originally, studies on immune-checkpoint inhibitors (ICIs) focused on certain...
Lucia’s research interests are in: translational medicine (particularly on genome and epigenome deregulation in cancer), stemness, differentiation, cell death processes, and the application of epigenome-based drug discovery approaches in human diseases. As a co-Editor-in-Chief, she is committed to...
Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, and metabolites. They mediate the exchange of substances between cells,thereby affecting biological properties and activities of recipient cells. I
This narrative review summarizes what is currently known about how SARS-CoV-2 infects cells and causes disease as a basis for considering whether
(Venkatesh); Department of Medicine, Critical Care and Hematology/Medical Oncology, University of Manitoba, Winnipeg, Manitoba, Canada (Zarychanski); Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California (Lewis); Department of Emergency Medicine, David Geffen School of ...
and translational researchers, all of whom were committed to finding novel medicines to treat diseases. The passion and drive of these academic researchers to explore the unknown would be hard to replicate within a pharmaceutical company, which are large, matrixed organizations that are generally risk...
This randomized clinical trial assesses the effect of treatment with an antiplatelet agent vs no antiplatelet therapy on days alive and free of intensive
After genomic DNA is tran- scribed to generate LncRNAs, some function in the nucleus, while others are translocated to the cytoplasm, where they can regulate mRNA stability, translational efficiency, and interfere with post-translational modifica- tions of proteins [26]. CircRNAs are also more ...
Markus, DM, FMedSci3 Author Affiliations Article Information JAMA Neurol. 2019;76(1):81-94. doi:10.1001/jamaneurol.2018.3122 Key Points Question What is the clinical and therapeutic significance of magnetic resonance imaging markers of covert vascular brain injury (white matter hyperintensities of ...