Lucia’s research interests are in: translational medicine (particularly on genome and epigenome deregulation in cancer), stemness, differentiation, cell death processes, and the application of epigenome-based
This open label clinical trial compares the effects of dexamethasone vs usual care on the number of days alive and free of mechanical ventilation at day
Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, and metabolites. They mediate the exchange of substances between cells,thereby affecting biological properties and activities of recipient cells. I
This narrative review summarizes what is currently known about how SARS-CoV-2 infects cells and causes disease as a basis for considering whether
2019, Journal of Translational Medicine Show abstract The human microbiome harbors a diverse array of microbes which establishes a mutually beneficial relation with the host in healthy conditions, however, the dynamic homeostasis is influenced by both host and environmental factors. Smoking contributes to...
After genomic DNA is tran- scribed to generate LncRNAs, some function in the nucleus, while others are translocated to the cytoplasm, where they can regulate mRNA stability, translational efficiency, and interfere with post-translational modifica- tions of proteins [26]. CircRNAs are also more ...
and translational researchers, all of whom were committed to finding novel medicines to treat diseases. The passion and drive of these academic researchers to explore the unknown would be hard to replicate within a pharmaceutical company, which are large, matrixed organizations that are generally risk...
Translational medicine: the antihypertensive effect of renal denervation Am J Physiol Regul Integr Compar Physiol, 298 (2010), pp. R245-R253 CrossrefView in ScopusGoogle Scholar 19 F. Mahfoud, M. Schlaich, I. Kindermann, et al. Effect of renal sympathetic denervation on glucose metabolism in ...
A systematic review of patients with cardiovascular disease found the use of complementary and alternative medicine was common among the patients, with varying prevalence ranging between 19% and 64% of whom were also taking prescription medications. There appeared to be little awareness that there may...
Despite host antiviral responses and antiretroviral therapy, HIV-1 continues to persist in myeloid cell reservoirs. Hence, strategies that promote the elimination of myeloid reservoirs are critically needed. Insight into host-HIV interactions is key to achieving a cure. ...