Infections clindamycin treats in adults and children include serious: Infections caused bysusceptible anaerobic bacteria Infections due tosusceptible isolates of streptococci, pneumococci, and staphylococci, if a less toxic alternative (such as erythromycin) is not suitable ...
aureus is encoded by the ermA or ermC genes and when of the macrolide-inducible variety is characterized by a positive erythromycin-clindamycin “D test”—a double-disk diffusion test in which the zone of inhibition around the clindamycin disk is blunted on the side facing the erythromycin disk...
Clindamycin provides high activity against pneumococci and group A streptococci; however, clinical isolates showing resistance to clindamycin and erythromycin have been increasingly reported from different areas, as already discussed under Erythromycin. One study of isolates ofS. pneumoniaefrom middle ears a...
Bacterial resistance may develop to clindamycin. Resistance to clindamycin may be associated with resistance to erythromycin. Also, cross-resistance has been demonstrated between clindamycin and lincomycin. Following multiple topical applications of clindamycin phosphate at a concentration equivalent to 10 mg ...