Clin Med Insights Oncol | 胰腺导管腺癌衍生外泌体的转录组标志物鉴定:促进巨噬细胞 M2 极化并预测预后 导语 结果: 鉴定外泌体来源的差异表达基因(DEGs)和功能注释 作者从exoRbase 2.0数据库中获取了164个PDAC衍生的外泌体和118个健康供体衍生的外泌体的转录组数据(图1A)。在组间差异表达基因分析中,作者获得了...
Clin Med Insights Oncol | 通过靶向肝癌细胞中的 ATG7 促进 FTH1 的自噬降解来抑制铁死亡 导语 结果: miR-339-5p 有助于肝癌进展 为了研究 miR-339 在肝癌中的作用,作者使用 TCGA 数据库分析了 miR-339 在肝癌中的 mRNA 表达水平,发现与正常组织相比,肝癌组织中 miR-339 的表达显着上调 (图1A).此外,作者...
3、Li C, Ren C, Wen L, et al. Heterogenous and Low Expression of HER2 in Breast Cancer Overcome by DS-8201a in a Heavily Treated Patient: Case Report and Review of the Literature. Clin Med Insights Oncol. 2022;...
廖宁教授团队发文CLIN MED INSIGHTS杂志,HER2低表达、高异质性的MBC,应用DS-8201后获得11个月OS ”关注我们, 然后点右上角“…”菜单,选择“设为星标” 15%～20%的乳腺癌患者存在HER2过表达或扩增。HER2阳性患者是指IHC评分3+或IHC 2+且ISH阳性,而IHC评分为1+或2+且ISH阴性则被定义为HER2低表达,但现行的HE...
Evidence-Based Care of Older Adults With Metastatic Colorectal Cancer: Insights From Landmark Clinical Trials. October 19, 2023 [MEDLINE Abstract] [Full-text from Publisher's Site] Elucidating the Benefit of Radiation Therapy in GI Cancers: Rethinking Trial End Points and Patient Selection. ...
Lab Med. 2020;51:649–54. 110. Cabitza F, Campagner A, Soares F, García de Guadiana-Romualdo L, Challa F, Sulejmani A, et al. The importance of being external. Methodological insights for the external validation of machine learning models in medicine. Comput Methods Programs Biomed. ...
Khan, K. A. & Kerbel, R. S. Improvingimmunotherapy outcomes with anti-angiogenic treatments and vice versa. Nat.Rev. Clin. Oncol. Pyonteck, S. M. et al. CSF-1R inhibitionalters macrophage polarization and blocks ...
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Am J Med Genet A 2012; 158A: 2519–2525. 29 Storm C, Agarwal R, Offit K: Ethical and legal implications of cancer genetic testing: do physicians have a duty to warn patients' relatives about possible genetic risks? J Oncol Pract 2008; 4: 229–230. 30 Clarke A, Richards M, Kerzin...
Clin Med Insights Oncol | 通过靶向肝癌细胞中的 ATG7 促进 FTH1 的自噬降解来抑制铁死亡 导语 结果: miR-339-5p 有助于肝癌进展 为了研究 miR-339 在肝癌中的作用,作者使用 TCGA 数据库分析了 miR-339 在肝癌中的 mRNA 表达水平,发现与正常组织相比,肝癌组织中 miR-339 的表达显着上调 (图1A).此外,...