clear cell renal cell carcinomacomputed tomographydeep learningradiomicssurvival analysisTo create a nomogram for accurate prognosis of patients with clear cell renal cell carcinoma (ccRCC) based on computed tomography images.#Eight hundred twenty-two ccRCC patients with contrast-enhanced computed tomography...
Identifying tumor-cell-specific markers and elucidating their epigenetic regulation and spatial heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA-seq and snATAC-seq in 34 and 28 human clear cell renal cell carcinoma (ccRCC) specimens, respectively, with matched bul...
Survival in Patients with Clear Cell Renal Cell Carcinoma Is Predicted by HIF-1 alpha Expression Aim: To investigate hypoxia inducible factor-1 alpha's (HIF-1 alpha) immunohistochemical expression in clear cell renal cell carcinoma (ccRCC) treated with... Minardi, DanieleLucarini, GuendalinaSantoni...
To test if a given signature predicts survival, we first computed the average expression of the signature in each tumor based on the bulk RNA-Seq data. Next, we stratified the patients into two groups according to the average expression of the signature: high or low expression correspond to t...
Clear cell renal cell carcinoma (ccRCC) is a complex disease with remarkable immune and metabolic heterogeneity. Here we perform genomic, transcriptomic, proteomic, metabolomic and spatial transcriptomic and metabolomic analyses on 100 patients with ccRCC from the Tongji Hospital RCC (TJ-RCC) cohort. ...
Clear-cell renal-cell carcinoma (ccRCC) is the most common pathological subtype of renal cell carcinoma (RCC), accounting for about 80% of RCC. In order to find potential prognostic biomarkers in ccRCC, we presented a four-gene signature to evaluate the prognosis of ccRCC. SurvExpress and immu...
Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer. Despite therapeutic advances, long term survival in patients diagnosed with advanced disease is low. Efforts to understand the mechanisms promoting disease progression will likely produce novel therapeutic targets. The un...
clear cell renal cell carcinoma lncRNAs: long non-coding RNAs TCGA: The Cancer Genome Atlas RNA-Seq: RNA sequencing OS: overall survival ROC: receiver operating characteristic K–M: Kaplan–Meier C-index: concordance index GSEA: gene set enrichment analysis FDR: false discovery rate...
Clear cell renal cell carcinoma (ccRCC) is a malignant tumor of the urinary system. To explore the potential mechanisms of DHODH in ccRCC, we analyzed its molecular characteristics using public databases. TCGA pan-cancer dataset was used to analyze DHODH expression in different cancer types and TC...
Clear cell renal cell carcinoma (ccRCC) is the most prevalent histological subtype of kidney cancer and is believed to mainly originate from proximal tubular epithelial cells of the nephron1. Genetically, ccRCC is characterized by biallelic loss of Von Hippel-Lindau tumor-suppressor gene that lead ...