CLCA2, a target of the p53 family, negatively regulates cancer cell migration and invasion. Cancer Biol Ther 2012; 13(14):1512- 1521. doi: 10.4161/cbt.22280 PMID: 22990203Y. Sasaki, R. Koyama, R. Maruyama et al., "CLCA2, a target of the p53 family, negatively regulates cancer cell...
Adhesion of blood-borne cancer cells to the endothelium is a critical determinant of organ-specific metastasis. Here we show that colonization of the lungs by human breast cancer cells is correlated with cell surface expression of the α6β4 integrin and adhesion to human CLCA2 (hCLCA2), a ...
CLCA2 is a p53-, p63-inducible transmembrane protein that is frequently downregulated in breast cancer. It is induced during differentiation of human mammary epithelial cells, and its knockdown causes epithelial-to-mesenchymal transition (EMT). To determine how CLCA2 promotes epithelial differentiation,...
is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. [provided by RefSeq, Sep ...
CLCA2 was reported as a tumor suppressor and disregulated in breast cancer. However, its function in tumor growth and metastasis in NPC has rarely been reported. In this study, we investigated the functional and molecular mechanisms by which CLCA2 influe
is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. [provided by RefSeq, Sep ...
Nutrition and Cancer A considerable amount of evidence indicates that tumorigenesis is associated with inflammation. Nuclear factor-kappa B (NF-kappa B), a master regulator of infection and inflammation, has been identified as a key modulator in which inflam... W Guo,EH Kong,M Meydani - 《...
Molecular Pathology of Gynecologic Cancer Background: In 2020, a new disease was reported by Polovitskaya et al., caused by a monoallelic, gain-of function mutation in CLCN6, encoding the ClC-6 Cl-... M Neumaier - 《Journal of Laboratory Medicine》 被引量: 0发表: 2008年 ...
CLCA2 tumour suppressor gene in 1p31 is epigenetically regulated in breast cancer . Oncogene 2004 ; 23 : 1474 - 1480 .X Li,JK Cowell,K Sossey-Alaoui.CLCA2 tumour suppressor gene in 1p31 is epigenetically regulated in breast cancer. Oncegene . 2004...
CLCA2 appears to primarily activate pathways such as EMT (epithelial-mesenchymal transition), RAS/MAPK, RTK, apoptosis, TSC/mTOR, and PI3K/ AKT in pan-cancer. On the other hand, it seems to inhibit pathways like cell cycle, DNA damage, hormone AR, and hormone...