However, the function, behavior and composition of the excipients need to be well known in the design, development and production of pharmaceutical dosage forms. In this review, excipients used to assist in any pharmaceutical dosage form production processes of drugs, to preserve, promote or ...
The interest in this classification system is largely because of its application in early drug development and then in the management of product change through its life cycle. BCS CLASSIFICATION According to the Biopharmaceutics classification system, the active pharmaceutical ingredients are classified as...
The absorption characteristics of drugs can be quantitatively described by numerous parameters, and are of enormous practical use in promoting pharmaceutical dosage form and new drug development [11]. Thus, the BCS study of PSVII can provide a theoretical basis for its formulation design and ...
Novel approaches for drug dissolution and biopharmaceutical classification of drugs The solubility and dissolution rate of active ingredients are of major importance in preformulation studies of pharmaceutical dosage forms. In the present ... Παπαδοπούλου, Βασιλική 被引量: ...
Second, insurance providers often only reimburse the lowest cost dosage form of a particular strength. Thus, if the efficacy and/or safety of an established active pharmaceutical ingredient are significanly improved by a novel topical formulation, the product may be either denied development as a ...
Ageing is a major risk factor for many conditions including cancer, cardiovascular and neurodegenerative diseases. Pharmaceutical interventions that slow down ageing and delay the onset of age-related diseases are a growing research area. The aim of this study was to build a machine learning model ...
Journal of Pharmaceutical SciencesH. Vogelpoel, J. Welink, and G. L. Amidon, et al., J. Pharm. Sci. , 93 , 1945 – 1956 (2004).Vogelpoel H, Welink J, Amidon GL, Junginger HE, Midha KK, Moller H, et al. Biowaiver monographs for immediate release solid oral dosage forms based ...
Dosage, toxicity and therapeutic efficacy of the therapeutic compounds can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD50 (the dose lethal to 50% of the population) and the ED50 (the dose therapeutically effective in 50...
Part 2: Application of homogeneity indices to solid pharmaceutical dosage forms. J. Pharm. Biomed. Anal. 70, 691–699. https://doi.org/10.1016/j.jpba.2012.06.037 (2012). Article CAS PubMed Google Scholar Li, Q., Wang, Y., Liu, H. & Chen, Z. in IEEE International Conference on ...
It permits self-administration, which provides patient acceptability, assists compliance and allows the pharmaceutical industry to meet this demand through the provision of adaptable and stable solid oral dosage forms. The apparent simplicity of this approach, however, hides a complexity arising from ...