Because of its vast genetic toolkit, Drosophila melanogaster is an ideal model system for understanding the underpinnings of behaviour. However, analysing behaviour is not trivial and therefore most studies rely
ofDrosophila melanogasterwas shown to contain thousands of smORFs of different classes that actively undergo translation, which produces peptides of mostly unknown function. Here, we present a comprehensive analysis of smORFs in flies, mice and humans. We propose the existence of several functional ...
These circular DNA were also seen in many other eukaryotic species, including yeast [8], Drosophila melanogaster [9], mice [10], hamsters [11] and human [12]. The majority of eccDNA found in normal cells is rather small and often less than 500 bp [10,[12], [13], [14], [15]]....
These methods have been applied to create connectomes for the Drosophila melanogaster brain6,18,19 and its ventral nerve cord.5,20 However, EM does not directly tell us about gene expression, most crucially the transmitter pathways active in each neuron. This gap hinders our understanding of key...
process of monoamine neurotransmitters [4]. Exocytosis in pancreatic beta-cells has been studied as well to understand insulin secretion.Drosophila melanogasteror fruit fly larvae have been used as a model organism to study the role of chemical neurotransmission in human neurodegenerative diseases [28]...
usefulness of geometric approaches for understanding the dynamics and function of specific, experimentally tractable, developmental regulatory systems comes from an analysis of the gap gene regulatory network involved in pattern formation during early embryogenesis of the vinegar fly Drosophila melanogaster. Ma...
Cingolani P, Platts A, Wang LL, Coon M, Nguyen T, Wang L, Land SJ, Lu X, Ruden DM (2012) A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w...
sinensis genome, analyzed their characteristics including gene structure, genome distribution, domains and specific sites by bioinformatic methods, and deduced phylogenetic relationships of all iGluRs in An. sinensis, Anopheles gambiae and Drosophila melanogaster. Based on the characteristics and phylogenetics...
The third type of microautophagy was recently discovered and studied in a murine dendritic cell line as well as in the fruit flyDrosophila melanogaster. It is also termed endosomal microautophagy and is characterized by endosomal invagination. The ESCRT machinery is an important component...
et al. Bishistidyl heme hexacoordination, a key structural property in Drosophila melanogaster hemoglobin. J Biol Chem 280, 27222–27229, doi: 10.1074/jbc.M503814200 (2005). 86. Becker, A. & Kabsch, W. X-ray structure of pyruvate formate-lyase in complex with pyruvate and CoA. How the ...