Exclusion criteria for the MNC were presence or history of major internal or neurological disorder, dependence on or recent abuse of alcohol or drugs, hypertension, and general MRI contraindications. BD and FOR2107 have similar exclusion criteria; details are described in Supplementary Table S1 and ...
Copper-chalcogenide-based materials (nanosize and microsize) are another class of inorganic agents that can be used for photomedicine. The d-d transition of electrons results in an absorption band over 900 nm. Hu and co-workers first reported the synthesis of microsized flower-like CuS particle...
The sequence annotation of EMRs can extract entities including diseases, symptoms, drugs, laboratory examinations, and the relationship between entities. This study is based on the current open-source method BiLSTM-CRF network [17], which performs sequence annotation well. Combined with the rule ...
Table 2 Agents under development or recently approved, and new and emerging indications of existing drugs for treating rosacea Full size table 2 Pathophysiology Current inflammatory pathways relevant to rosacea pathogenesis include dysregulation of immune (innate, adaptive, inflammasome) and neurocutaneous ...
Gaps in Definitions According to Trajectory of Changes in HF Learning From Other Disease Definitions Proposed Universal Definition of HF Other Syndromes Related to HF Proposed Revised Stages of the HF Continuum NYHA Functional Classification Recognition of Clinical Trajectory in HF Acute versus Decompensated...
Artificial-intelligence-driven deep-learning models have been widely used in drug design, but traditional models may produce incorrect results for samples that fall outside the coverage of the original training datasets. This can lead to an influx of unreliable prediction results into subsequent drug ...
of the drugs or treatment in the small animal model then warrants further testing in larger animals before clinical studies in humans. However, the drugs, though shown to be efficacious in small animal studies, may not be translatable to human with equal efficacy [17]. A reason for this ...
With the development of nonlinear optics and new imaging methods, near-infrared (NIR) light can excite contrast agents to probe biological specimens both functionally and structurally with a deeper imaging depth and a higher spatial resolution than linea
First, we present a new massive dataset of breast cancer cell images of the JIMT-1 breast cancer cell line15. We studied cellular growth before and after the introduction of in vitro drugs treatments with Doxorubicin and Paclitaxel. After characterizing the biological behavior within chambered covers...
There are many drugs, which have similar therapeutic mechanisms, for the treatment of breast cancer. To a certain extent, the therapeutic mechanisms of these drugs can reflect the pathogenesis of breast cancer35. We believe that the feature genes from the ensemble should be related to the ...