An agent which specifically inhibits a response produced by an adrenergic agonist is referred to as adrenergic blocking agent or adrenergic antagonist.doi:10.1007/978-3-642-65249-3_9FURCHGOTT,RFSpringerHandbuch Der Experimentellen Pharmakologie
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Metomidate like etomidate inhibits cortisol synthesis resulting in reduced response to adrenergic sti- mulation . The l a t t e r mechanism could be responsible f o r the short survival time of group KM. This study demonstrates, that results from septic animal models strongly depend on the ...
The pharmacological classification of adrenergic α 1 and α 2 receptors and their mechanisms of action... JES Wikberg 被引量: 94发表: 1979年 Pharmacological classification of adenosine receptors in the sinoatrial and atrioventricular nodes of the guinea-pig The effects of seven agonist and three ...
Mechanism of actionElectrolyte with antiarrhythmic effects, regardless of blood magnesium levels. EffectsMembrane stabilization. DeliveryIV Dose20 mmol IV over 20 min, then 20 mmol every 20 hour. Bretylium DrugBretylium Brand namesVF (ventricular fibrillation) ...
ciliary body cell membranes were determined by direct binding of radioactive dihydroalprenolol (DHA), yohimbine (YOH), WB-4101 (WB) and prazosin (PRZ), classified respectively as β 1 + β 2, α 2, α 1, and α 1 subtype selective ligands (based on binding to brain adrenergic ...
Two histamine H 1 -antagonists, astemizole and ketotifen; the serotonin S 2 -antagonist ketanserin; and the 伪-adrenergic blocking agent prazosin were tested over a wide dose range 2 hr after s.c. administration. Prazosin, as a result of systemic hemodynamic effects, significantly inhibited ...
We report a case of recurrent priapism in a sickle cell patient who had undergone physiological transformation from a low-flow state to a mixed high-flow/low-flow picture. An oral alpha-adrenergic agonist/histamine-1 antagonist combination maintained a balance of potency without stutter in the ...
Examples of pathways include acetylcholine, adenosine, epinephrine, glucagon, or beta-adrenergic agonists like isoproterenol and the vasoactive intestine peptide (VIP). It is believed that phosphorylation of the R domain enhances the channel activity and also stimulates the opening of CFTR channels. In...
reported 5-HT1A and α1-adrenergic receptor (α1-AR) receptor binding properties of a series of 23 thienopyrimidinones using HASL 3D-QSAR models. And the multiconformer 3D-QSAR model was demonstrated to yield robust cross-validated models for the 23 thienopyrimidinones, which were more ...