Epidermal growth factor (EGF) ligand release by substrate-specific a disintegrin and metalloproteases (ADAMs) involves different protein kinase C (PKC) isoenzymes depending on the stimulus. J Biol Chem. 2011;286:17704–13. CAS PubMed PubMed Central Google Scholar Geribaldi-Doldan N, Gomez-...
This result shows that AR-NC retains non-classical pathway functionality because increased p-ERK expression indicates that the mitogen-activated protein kinase (MAPK) pathway is activated in the presence of AR-NC. Similarly, the AR-C transgene retained classical pathway activity because expression of...
The reversible EMT pathway to metastasis is well-worked out in the context of TGF-β signaling as described above. However, the signaling intermediates such as the TAK1 exon-12 variant (not wild-type),38and epigenetic remodeling by altered PRC2 complex function35,92compromise the cell death-in...
Proinflammatory NF-kappaB activation requires the IkappaB (inhibitor of NF-kappaB) kinase (IKK) complex that contains two catalytic subunits named IKKalpha and IKKbeta and a regulatory subunit named NF-kappaB essential modulator (NEMO). NEMO and IKKbeta are essential for tumor necrosis factor (TNF...
PD-L1 programmed death-ligand 1 SIRPα signal regulatory protein alpha SP-D surfactant protein-D SPEM spasmolytic polypeptide-expressing metaplasia TFF2 trefoil factor 2 Treg regulatory T cell WT wild type XCR1 X-C motif chemokine receptor 1 ZBTB46 zinc finger and BTB domain containing 46 ...
Rimm DL, Koslov ER, Kebriaei P, Cianci CD, Morrow JS (1995) Alpha(1)(E)-catenin is an actin-binding and actin-bundling protein mediating the attachment of F-actin to the membrane adhesion complex. Proc Natl Acad Sci U S A 92:8813–8817 Article PubMed CAS Google Scholar Rose R, ...
RNA activated protein kinase PLWH: People living with HIV ROS: Reactive oxygen species RNA: Ribonucleic acid RNS: Reactive nitrogen species PBMC: Peripheral blood mononuclear cell SAMHD1: Sterile alpha motif and histidine/aspartic acid domain containing protein 1 ...
RNA activated protein kinase PLWH: People living with HIV ROS: Reactive oxygen species RNA: Ribonucleic acid RNS: Reactive nitrogen species PBMC: Peripheral blood mononuclear cell SAMHD1: Sterile alpha motif and histidine/aspartic acid domain containing protein 1 ...
Requirement for LMP1- induced RON receptor tyrosine kinase in Epstein-Barr virus-mediated B-cell proliferation. Blood 2011;118: 1340–1349. 47 Doussis-Anagnostopoulou IA, Vassilakopoulos TP, Thymara I, et al. Topoisomerase IIalpha expression as an independent prognostic factor in Hodgkin's lym...
(receptor-type tyrosine protein phosphatase kappa) (Fig.1). Downregulation ofPTPRKby the EBV-encoded EBNA1 contributes to the growth and survival of HRS cells13. The 6q23.3 association defined by rs6928977 localises to intron 3 ofAHI1(abelson helper integration site-1) (Fig.1) which has ...