'We Have Two Classes of Cancer Patient: Those with Health Insurance and Those without'; Britain Is at the Forefront of Cancer Research. Yet at the NHS Front Line, Patients Are Being Denied Access to Revolutionary New Drugs on Cost Grounds. Can the War against the Disease, Which Claims 156...
Features Completely updated to reflect new classes of cancer drugs, including targeted biologicals NEW 9 additional international contributors NEW chapters: Pregnancy and Chemotherapy; Hematologic Complications of Pregnancy; Hemochromatosis NEW "... MM Boyiadzis,PF Lebowitz,JN Frame,... 被引量: 33发表...
1. Cancer Drugs Drugs used during chemotherapy have long been linked to Raynaud’s. Specifically, cisplatin and bleomycin were most likely to induce the phenomenon, the researchers found. Additionally, evidence suggests “a possible involvement of tyrosine kinase inhibitors,” such as imatinib (Gleevec...
cancerDimerdrug designmedicinal chemistryPolyvalency in the biological world is defined as the simultaneous binding of multiple ligands to one receptor. Polyvalency can increase the affinity of the polyvalent ligand by 100-1000 fold over the monovalent ligand. Such phenomenon has been employed to ...
2006. A noninvasive method for detection of intestinal mucositis induced by different classes of chemotherapy drugs in the rat . Cancer Biol Ther 5 :1189–1195Howarth G. S., Tooley K. L., Davidson G. P., Butler R. N. A non-invasive method for detection of intestinal mucositis induced ...
Using this model, structure-based virtual screening was performed using compounds from NCI (National Cancer Institute) Diversity Set II, ChemBridge, ZINC natural products, and FDA-approved drugs databases. Several potential ligands were identified using molecular docking. In order to validate the anti...
Causes a similar adverse health outcome regardless of mechanism of action (e.g., cancer, disruption of male sexual development; hypothyroidism); Causes toxicity by the same mode of action or molecular mechanism (e.g., inhibition of acetylcholinesterase); Similar intrinsic hazard traits (e.g., en...
In oncology, there is a trend towards the development of 'armed' antibody products, in which the immunoglobulin moiety serves for the selectivein vivopharmacodelivery of bioactive payloads such as cytotoxic drugs, bispecific antibodies, radionuclides or cytokines to sites of disease, thereby sparing ...
Being female showed a consistent negative effect on persistence for all drugs but showed heterogeneous effects on adherence. Age also showed heterogeneous effects across different medications (Supplementary Data 3–6). Extending beyond these baseline factors, we further assessed the effect of one or ...
Russell synthesis and study of structure-activity relationships of new classes of anthracyclines, Antonino Suarato et al molecular recognition of DNA by ... Priebe,Waldemar 被引量: 0发表: 1994年 Cancer Chemotherapy: Principles and Practice In: Chabner BA, Collins JM (eds) Cancer chemotherapy: pr...