FDA added new safety labeling changes for a class of antibiotics, fluoroquinolones (Levaquin, Cipro and other branded drugs), to enhance warnings about their association with disabling and potentially permanent side effects. Plus, the new labeling says that the drugs' use should be limited in ...
Conclusions: We have illustrated that the FR class of anti-tumor antibiotics, represented in this study by FR900482, is able to produce covalent cross-links between the HMG I/Y oncoproteins and DNA in vivo. The ability of this class of compounds to cross-link the HMG I/Y proteins in ...
The development of new antibiotics to treat infections caused by drug-resistant Gram-negative pathogens is of paramount importance as antibiotic resistance continues to increase worldwide1. Here we describe a strategy for the rational design of diazabicyclooctane inhibitors of penicillin-binding proteins...
YQ Xiong,MR Yeaman,AS Bayer - 《Drugs of Today》 被引量: 61发表: 2000年 Effect of antibiotics, alone and in combination, on Panton-Valentine leukocidin production by a Staphylococcus aureus reference strain. The capacity of Staphylococcus aureus strain LUG855 to release PantonValentine leukocid...
- 《Journal of Antibiotics》 被引量: 249发表: 2013年 International collaboration in drug discovery and development: the NCI experience The past century, however, has seen an increasing role played by micro-organisms in the production of antibiotics and other drugs for the treatment of ... GM ...
E. Initial efforts toward the optimization of arylomycins for antibiotic activity. J. Med. Chem. 54, 4954–4963 (2011). CAS Google Scholar Therien, A. G. et al. Broadening the spectrum of β-lactam antibiotics through inhibition of signal peptidase type I. Antimicrob. Agents Chemother. ...
Linezolid Is the First of a New Class of Antibiotics 来自 drplace.com 喜欢 0 阅读量: 11 作者: text editor 摘要: Reviews the activity and clinical use of linezolid, the first oxazolidinone approved for use in the U.S. Ways linezolid exerts its antimicrobial effect; Recommended dosage; ...
New Drugs: Tigecycline, Ziconotide, and Clofarabine The approval of tigecycline (Tygacil-Wyeth) represents an important step in the development of new antibiotics active against certain bacteria resistant to many of the previously marketed antibiotics. Designated by some as the first of a ... Hussar...
The findings provide some good news for Merck, which is racing against GlaxoSmithKline to bring a cervical cancer 360 | MAY 2005 | VOLUME 4 www.nature.com/reviews/drugdisc NEWS & ANALYSIS novel class of antibiotics called pleuromutilins, and two target-based projects will work on the enzymes ...
Antibiotic susceptibility of the isolates was determined by standard disk diffusion method on Mueller-Hinton agar (Oxoid) according to the guidelines and breakpoints of Clinical and Laboratory Standards Institute [3]. The isolates were tested for susceptibility to 15 antibiotics representing seven classes...