The class III phosphatidylinositol-3-kinase (PI3KC3) plays a central role in autophagy and endocytosis. How its function is differentially regulated in these processes remain elusive. We are the first group to purify PI3KC3 holocomplex i... Q Zhong - 《Faseb Journal》 被引量: 10发表: 2013年...
内容提示: Class III PI3K Vps34 plays an essential role inautophagy and in heart and liver functionNadia Jabera, Zhixun Doua, Juei-Suei Chena, Joseph Catanzaroa, Ya-Ping Jiangb, Lisa M. Ballouc, Elzbieta Selingerb,Xiaosen Ouyangd, Richard Z. Linb,e, Jianhua Zhangd,f,1, and Wei-Xing...
Partial inhibition of class III PI3K VPS-34 ameliorates motor aging and prolongs health spandoi:10.1371/journal.pbio.3002165PHOSPHATIDYLINOSITOL 3-kinasesOLDER peopleAGINGREGULATOR genesMYONEURAL junctionLIFE expectancyGlobal increase of life expectancy is rarely accompanied by ...
- 《Journal of Cell Biology》 被引量: 0发表: 2010年 Cell-specific roles of p110β in myocardial ischemia The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy . J Cell Biol 2010 ; 191 : 827 – 843 . 4 Lin Z... Ghigo Alessandra - 《...
Thus, class III PI3K activity was also required for the accumulation of PI(4,5)P2 and PI(3,4,5)P3 and for actin tail formation. These experiments reveal a new PI(3)P-sensitive pathway leading to PI(3,4)P2 and PI(3,4,5)P3 formation and signaling in endomembranes.Bohdanowicz...
Class IA PI3Ks are involved in the generation of the key lipid signaling molecule phosphatidylinositol 3,4,5-trisphosphate (PIP3), and inappropriate activation of this pathway is implicated in a multitude of human diseases, including cancer, inflammation, and primary immunodeficiencies. Class IA ...
Class II PI3Ks [6,7] and type Iα 4-phosphatase [8] may generate a pool of PtdIns3P at the plasma membrane while the class III PI3K (also called Vps34) and Fig4 could be responsible for the control of the endosomal pool [9]. It is noteworthy that class III PI3K also plays a ...
ARTICLE Received 7 Nov 2014 | Accepted 5 Feb 2015 | Published 17 Mar 2015 DOI: 10.1038/ncomms7535 The class II PI 3-kinase, PI3KC2a, links platelet internal membrane structure to shear-dependent adhesive function Jessica K. Mountford1, Claire Petitjean1, Harun W. Kusuma Putra1, Jonathan A...
Phosphoinositide 3-kinases (PI3Ks) are a family of lipid enzymes divided into three classes (I–III) each with its own substrate specificity, structures and lipid products6,7,8. Class I PI3Ks are heterodimers composed of a p110 catalytic subunit (α, β, γ or δ) and a p85/p55/p50 ...
The class IB PI3K, PI3Kγ, is a heterodimeric complex composed of a catalytic p110γ subunit bound to a p101 or p84 regulatory subunit. PI3Kγ is a critical component in multiple immune signaling processes and is dependent on activation by Ras and G protein-coupled receptors (GPCRs) to ...