it is pivotal in maintaining the spatial alignment between the VFTs and CRDs mainly via an inter-domain disulfide bond. On the other hand, the significant mobility of the B2’ module allows it to act as a structural “pioneer”, adept at receiving, amplifying, and forwarding signals ...
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Matthieu Schapira, Mike Tyers, Maricel Torrent & Cheryl H. Arrowsmith 18k Accesses 38 Altmetric Explore all metrics Key Points WD40 repeat (WDR) domains are β-propeller domains that act as protein interaction scaffolds in multiprotein complexes. WDR domain-containing proteins comprise one of ...
WD40 repeat (WDR) domains are β-propeller domains that act as protein interaction scaffolds in multiprotein complexes. WDR domain-containing proteins comprise one of the largest protein families in humans and are involved in a diverse array of cellular networks, many of which are disease-associate...
evolutionary derived mainly from host-pathogen interactions49. The host-parasite relationships might have led to MHC polymorphism through balancing selection: heterozygote advantage, negative frequency-dependent selection, or fluctuating selection pressures may act, also synergistically, to maintain MHC ...