The ability of superparamagnetic iron oxide nanoparticles (SPIONs) to shorten the effective transverse relaxation time (T2) during magnetic resonance imaging (MRI) makes them excellent contrast agents in diagnostic applications. Here we describe a new class of hybrid MRI contrast agent using dispersions...
Here we report the synthesis of perfluoropolyether (PFPE) end-functionalized homopolymers of oligo(ethylene glycol) methyl ether acrylate (poly(OEGA)m-PFPE) as highly sensitive 19F MRI contrast agents (CAs). The structural characteristics, conformation and aggregation behavior, 19F NMR relaxation ...
By virtue of their hydrophilicity and abundant exchangeable protons of hydroxyl, amine, and amide anchored on the surface, we report here that C‐dots can be adapted as effective diamagnetic CEST (diaCEST) MRI contrast agents. As a proof‐of‐concept demonstration, human glioma cells were ...
tuberculosis infection demonstrated that ganfeborole at 2 mg/kg/day and 0.5 mg/kg/day per day for 8 weeks led to a mean decrease in bacterial burden by 2.7 and 2.6 log10colony-forming units (CFUs)/lung lesion, respectively21. A phase 1 study assessed the safety, tolerability and...
Giovanni B.Giovenzana,RobertoNegri,Gabriele A.Rolla,LorenzoTei.Gd‐Aminoethyl‐DO3A Complexes: A Novel Class of pH‐Sensitive MRI Contrast Agents[J]. Eur. J. Inorg. Chem. .2012(12)Gd‐Aminoethyl‐DO3A Complexes: A Novel Class of pH‐Sensitive MRI Contrast Agents[J] . Giovanni B.Giovenzana...
Here, MD simulations and the D(胃) relationship are shown to accurately predict the relaxometric responses of Gd(DOTA) or SPIOn MRI contrast agents confined within hydrated nanopores, proving that the D(胃) scaling law can help in ... M Fasano 被引量: 0发表: 2015年 加载更多0...
M184V HIV-2 RT. In contrast, K65R had minor effects on the catalytic constants determined in these assays, while Q151M produced a modest increase in the catalytic efficiency of the HIV-2 RT, despite reducing the nucle- otide binding affinity by two-fold. Interestingly, in comparison with...
Small (≤3 cm) hepatocellular carcinoma in cirrhosis: the role of double contrast agents in MR imaging vs. multidetector-row CT Purpose We prospectively compared gadoliniumenhanced magnetic resonance imaging (dynamic MRI), superparamagnetic iron oxide (SPIO) (ferucarbotran) MRI and ... R Golfieri...
the treatment was at least 28 days prior to initiation of study drug, and baseline brain computed tomography (CT) with contrast or magnetic resonance imaging (MRI) within 14 days of initiation of study drug, is negative for new or worsening brain metastases. (7) Other concurrent chemotherapy,...
www.nature.com/scientificreports OPEN Discovery of Radioiodinated Monomeric Anthraquinones as a Novel Class of Necrosis Avid Agents received: 25 November 2015 accepted: 21 January 2016 Published: 16 February 2016 for Early Imaging of Necrotic Myocardium Qin Wang1,2,*, Shengwei Yang1,2, Cuihua...