Class 1C antiarrhythmic drugs (AADs) are effective first‐line agents for atrial fibrillation (AF) treatment. However, these agents commonly are avoided in patients with known coronary artery disease (CAD), due to known increased risk in the postmyocardial infarction population. Whether 1C AADs ...
Classification of antiarrhythmic drugs in relation to mechanisms of arrhythmias A modification of the classification of Na + channel blocking agents was provided by Harrison et al. [4], who subdivided class I actions into the classes a, b and c, mainly on the basis of the effects on action ...
6.33.5.2.1.1 Class 1 antiarrhythmic drugs are all sodium channel blockers All Class 1 drugs block cardiac sodium channels. However, on the basis of the frequency-dependent nature of the block, and the presence or absence of concomitant potassium channel blocking actions resulting in action potentia...
Ibutilide is the first class III antiarrhythmic agent to rely on activation of a slow inward sodium current to prolong the action potential and effective refractory period of atrial and ventricular tissue. The drug is indicated for the rapid restoration of normal sinus rhythm in patients with ...
clonazepam and diazepam CARDIOVASCULAR AGENTS Class Examples Alpha1 Blockers Terazosin, prazosin Considerations Also see urinary agents for more information Alpha2 Agonists5,9 Antiarrhythmic Agents5 Beta Blockers5,10,11 Clonidine, guanfacine, methyldopa Amiodarone, digoxin, dofetilide...
Quinidine, procainamide and disopyramide are antiarrhythmic drugs in the class 1A category. These drugs have a low toxic to therapeutic ratio, and their use is associated with a number of serious adverse effects during long term therapy and life-threatening sequelae following acute overdose. ...
Background:Class 1C antiarrhythmic drugs (AADs), such as flecainide and propafenone, are effective first-line agents for rhythm control in atrial tachyarrhythmias. The Cardiac Arrhythmia Suppression Trial (CAST) suggested class 1C AADs increase mortality in patients with myocardial ischemia, limiting...
Feld GK,,Chen PS,Nicod P,et al.Possible atrial pro-arrhythmic effects of class1C antiarrhythmic drugs. The American Journal of Cardiology . 1990Feld GK, Chen PS, Nicod P, Fleck RP, Meyer D. Possible atrial proar- rhythmic effects of class 1C antiarrhythmic drugs. Am J Cardiol. 1990; ...
Schweizer,Rüdiger Becker,Hugo A. Katus,Dierk Thomas.European Journal of Pharmacology . 2013 (1-3)C. Schmidt, F. Wiedmann, P.A. Schweizer, et al., Class I antiarrhythmic drugs inhibit human cardiac two-pore-domain K+ (K2P) channels, Eur. J. Pharmacol. 721 (2013) 237-248....
Evidence for the possible involvement of Ca2+ entry blockade in the relaxation by class I antiarrhythmic drugs in the isolated pig coronary smooth muscle. Naunyn Schmiedebergs Arch Pharmacol. 2002;365(1):56-66.Tanaka Y, Kamibayashi M, Yamashita Y, Imai T, Tanaka H, Nakahara T, Ishii K, ...